11 documents found, page 1 of 2

Causa Rara de Disfunção Ventricular Esquerda em Adultos

Pseudoappendicitis due to Yersinia pseudotuberculosis: A Case Report with a Fat...

Yersinia species often cause enterocolitis or pseudoappendicitis. Yersiniosis is mostly transmitted by raw or undercooked foods, namely pork. Clinical severity is related to states of immunosuppression or iron overload. We present the clinical case of a 79-year-old man with a history of hypertension and diabetes, who was admitted to the emergency department for right low back pain with anterior irradiation to t...

Crioglobulinémia Mista e VIH

Sternal Mass: A Rare Case of Primary Hodgkin Lymphoma of The Bone

Sternal tumour lesions remain a challenge in clinical practice. Due to multiple etiologies, it can be difficult to diagnose primary bone Hodgkin lymph, often misdiagnosed as tuberculosis or eosinophilic granuloma. The authors report the case of a 32-year-old patient with non-specific sternal chest pain that had lasted approximately one year as the initial presentation of primary Hodgkin lymphoma of the sternum,...

Exuberant Cushing Syndrome, due to a Rare Adrenal Cortex Carcinoma

Gastric Cancer Initially Presenting as Paraparesis

Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and pr...

Activation of immune cells in response to fungal infection involves the reprogramming of their cellular metabolism to support antimicrobial effector functions. Although metabolic pathways such as glycolysis are known to represent critical regulatory nodes in antifungal immunity, it remains undetermined whether these are differentially regulated at the interindividual level. In this study, we identify a key role...

A crown for each monarch: a distinguishable pattern using photo-identification

Photo-identification has been proven to be a successful individual recognition tool in seahorse species (e.g., long-snout seahorse Hippocampus reidi (Ginsburg, 1933) and long-snouted seahorse Hippocampus guttulatus (Cuvier, 1829)). Its use was deemed valuable for the assessment of wild populations and to understand variations in abundance over time when capture-recapture methods are needed. In this study, a com...

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promot...

In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an essential molecule required for the metabolic rewiring of macrophages during infection with the fungal pathogen Aspergillus fumigatus. Using pharmacological and genetic tools, we reveal a molecular link between calcium sequestrat...

Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Asperg...

Purpose of Review There is significant interindividual variability in the development and progression of fungal diseases, most notably invasive pulmonary aspergillosis (IPA). The integration of individual traits into clinically valid procedures to predict the risk and progression of infection, and the efficacy of antifungal prophylaxis and therapy, will change the current healthcare landscape regarding the mana...