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Diabetes mellitus and prostate cancer metabolism: Is there a relationship?

Antunes, Hugo Pontes; Teixo, Ricardo; Carvalho, João André; Eliseu, Miguel; Marques, Inês; Mamede, Ana; Neves, Rita; Oliveira, Rui

Objective: Our aim was to evaluate the effects of glucose levels and diabetes mellitus in prostate cancer (PCa) biology. Materials and methods: Two PCa cell lines (LNCap and PC3) were cultured in RPMI medium with different glucose concentrations [5mM (LG) and 25mM (HG)]. Expressions of androgen receptor, Her2/neu and glucose transporters (GLUT1, 3, 5 and 12) were evaluated by flow cytometry. Proliferation rate ...

Date: 2018   |   Origin: Estudo Geral - Universidade de Coimbra
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