35 documents found, page 1 of 4
Lyocell/silver knitted fabrics for prospective diabetic foot ulcers treatment: ...
Tavares, Tânia Daniela Eugénio; Ribeiro, Artur; Bengoechea, Carlos; Rocha, Diana; Alcudia, Ana; Begines, Belén; Silva, C.; Antunes, Joana Isabel CostaDiabetic foot ulcers (DFUs) are a serious complication of diabetes, often resulting in infections and further health deterioration. Thus, the development of an approach combining different therapies in just one formulation to treat DFUs remains very challenging. Silver-plated polyamide fibers offer antimicrobial properties, while lyocell provides biodegradability, biocompatibility and moisture management abilit...
Thymol-loaded polycaprolactone wet-spun fibers and their ability to suppress ba...
Teixeira, Marta Sofia Aguiar Carvalho Oliveira; Pérez, Leonardo M; Pinho, Sonia L C; Ferreres, Guillem; Rocha, Diana; Freitas, David S; Tzanov, TzankoChronic wounds (CWs) are labeled as a significant clinical challenge due to their complex treatment, often hindered by bacterial colonization and persistent inflammation. In this study, the potential of wet-spun polycaprolactone (PCL) fibers embedded with thymol (PCL-thy), a natural antibacterial, anti-inflammatory and antioxidant compound, was investigated for the treatment of CWs. The incorporation of thymol ...
Combinatory effect of nisin antimicrobial peptide with bioactive molecules: a r...
Tavares, Tânia Daniela Eugénio; Ribeiro, Ana R. M.; Silva, Carla Joana Santos Marinho; Antunes, Joana Isabel Costa; Felgueiras, Helena PradoThe global concern over the emergence of antibiotic-resistant pathogens is growing, demanding for new and more effective antimicrobial strategies. Antimicrobial peptides (AMPs) have been the focus of great interest as alternatives to antibiotics. Nisin, a naturally occurring AMP, possesses unique characteristics such as an uncommon structure, amphiphilic nature, low likelihood of promoting bacterial resistance,...
Nanoparticle synthesis and their integration into polymer-based fibers for biom...
Domingues, Joana Margarida Dias; Miranda, Catarina S.; Homem, Natália Cândido; Felgueiras, Helena Prado; Antunes, Joana Isabel CostaThe potential of nanoparticles as effective drug delivery systems combined with the versatility of fibers has led to the development of new and improved strategies to help in the diagnosis and treatment of diseases. Nanoparticles have extraordinary characteristics that are helpful in several applications, including wound dressings, microbial balance approaches, tissue regeneration, and cancer treatment. Owing t...
Pullulan hydrogels as drug release platforms in biomedicine
Teixeira, Marta Sofia Aguiar Carvalho Oliveira; Marinho, Elina Margarida Ribeiro; Silva, C.; Antunes, Joana Isabel Costa; Felgueiras, Helena PradoIt is increasingly urgent to develop new therapeutic systems to combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder the patient's recovery. In this sense, a targeted and controlled delivery of various biomolecules allows overcoming the limitations of conventional delivery systems, taking the user one step closer to...
Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced...
Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Fertuzinhos, Aureliano Costa; Tohidi, Shafagh Dinparast; Reis, SaletteInfection is a major issue in chronic wound care. Different dressings have been developed to prevent microbial propagation, but an effective, all-in-one (cytocompatible, antimicrobial and promoter of healing) solution is still to be uncovered. In this research, polyvinyl alcohol (PVA) nanofibrous mats reinforced with cellulose nanocrystal (CNC), at 10 and 20% v/v ratios, were produced by electrospinning, crossl...
Bacterial nanocellulose films loaded with nisin Z -antibacterial efficacy again...
Tavares, Tânia Daniela Eugénio; Melro, Liliana Sofia Silva Ferreira Pinto; Antunes, Joana Isabel Costa; Silva, C.; Dourado, Fernando; Gama, F. M.Burn wounds can lead to numerous severe complications including bacterial infections causing patient morbidity and mortality, mostly in low- and middle-income countries. The Grampositive bacteria Staphylococcus aureus is one of the major causes of nosocomial infections in burn patients. Furthermore, the considerable increase of the microbial resistance against traditional antibiotics is leading towards alternat...
Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose ac...
Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Tohidi, Shafagh Dinparast; Reis, Salette; Amorim, M. T. Pessoa deIn this research, we propose to engineer a nanostructured mat that can simultaneously kill bacteria and promote an environment conducive to healing for prospective wound care. Polyvinyl alcohol (PVA) and cellulose acetate (CA) were combined at different polymer ratios (100/0, 90/10, 80/20% v/v), electrospun and crosslinked with glutaraldehyde vapor. Crosslinked fibers increased in diameter (from 194 to 278 nm),...
Extraction of cellulose-based polymers from textile wastes
Felgueiras, Helena Prado; Padrão, Jorge; Antunes, Joana Isabel Costa[Excert] The extraction and exploration of cellulose-based polymers is an exciting area of research. For many years, wood (especially from bleached kraft wood pulp) was considered the main source of cellulosic compounds because of its abundance in nature [1,2]. However, in the past decade, researchers have been devoted to finding alternatives to extract cellulose from byproducts of agricultural crops and/or tex...
Graphene oxide-based platforms for wound dressings and drug delivery systems: A...
Homem, Natália Cândido; Miranda, Catarina S.; Teixeira, Marta A.; Teixeira, Marta Sofia Aguiar Carvalho Oliveira; Domingues, Joana Margarida DiasIn the past few years, the outstanding properties of the best-known derivative of graphene, the graphene oxide (GO), have led to a wide increase of its spectra of application. GO-based composites have been reported as chemically and mechanically stable, presenting good biocompatibility and great antimicrobial potential. Also, GO's two-dimensional planar structure coupled with its large availability of oxygen-re...