21 documents found, page 1 of 3
Histomorphometric analysis of the human internal thoracic artery and relationsh...
Fonseca, DA; Antunes, PE; Antunes, MJ; Cotrim, MDIn this study, we aimed at performing a histomorphometric analysis of human left internal thoracic artery (ITA) samples as well as at correlating the histomorphometric findings with the clinical profile, including risk factors and medication. Distal segments of ITA were obtained from 54 patients undergoing coronary artery bypass grafting. Histological observation was performed in paraffin-embedded transverse se...
Vascular effects of a polyphenolic fraction from Oxalis pes-caprae L.: role of ...
Fonseca, DA; Ferreira, M; Campos, MG; Antunes, PE; Antunes, MJ; Cotrim, MDOxalis pes-caprae L. is a plant of the Oxalidaceae family, from which several compounds have been previously identified. Recently, we showed that an Oxalis pes-caprae L. extract inhibits the vasopressor effect of noradrenaline. In this work we aimed to explore the mechanisms involved in this effect. The results confirmed that the flavonoid fraction present in the extract inhibits noradrenaline-induced contracti...
Coronary artery bypass surgery in young adults: excellent perioperative results...
Saraiva, J; Antunes, PE; Antunes, MJOBJECTIVES: To analyse perioperative results, long-term survival and freedom from complications after coronary artery bypass grafting (CABG) in young adults. METHODS: A total of 163 patients, 40 years old or younger, had isolated CABG from January 1989 to December 2010. Pre- and perioperative demographic and clinical data were retrieved from a prospectively organised database. Follow-up data were obtained by le...
Coronary artery bypass surgery without cardioplegia: hospital results in 8515 p...
Antunes, PE; Ferrão de Oliveira, J; Prieto, D; Coutinho, GF; Correia, P; Branco, CF; Antunes, MJOBJECTIVES: Cardioplegic myocardial protection is used in most cardiac surgical procedures. However, other alternatives have proved useful. We analysed the perioperative results in a large series of patients undergoing coronary artery bypass (CABG) using cardiopulmonary bypass (CPB) and non-cardioplegic methods. METHODS: From January 1992 to October 2013, 8515 consecutive patients underwent isolated CABG with C...
A decade of cardiac transplantation in Coimbra: the value of experience
Prieto, D; Correia, P; Batista, M; Sola, E; Franco, F; Costa, S; Antunes, PE; Antunes, MJINTRODUCTION AND OBJECTIVES: To analyze the experience gained in 10 years of the heart transplantation program of the University Hospital of Coimbra. METHODS: Between November 2003 and December 2013, 258 patients with a mean age of 53.0±12.7 years (3-72 years) and predominantly male (78%) were transplanted. Over a third of patients had ischemic (37.2%) and 36.4% idiopathic cardiomyopathy. The mean age of donors...
Aortic valve surgery in patients who had undergone surgical myocardial revascul...
Paupério, GS; Pinto, CS; Antunes, PE; Antunes, MJOBJECTIVES: A very high percentage of patients submitted to coronary artery bypass grafting (CABG) develop symptomatic aortic disease requiring surgery upon ageing. The surgical risk of the redo procedure is controversial. We describe our recent experience with patients submitted to this surgery under such conditions. METHODS: From July 1999 to July 2010, 51 patients (mean age, 70.3 ± 7.0 years, 86.3% male) sub...
Transplantação cardíaca: cinco anos de actividade
Antunes, MJ; Prieto, D; Sola, E; Antunes, PE; Oliveira, JF; Franco, F; Providência, LAOBJECTIVE: To analyze the initial five years experience of the new heart transplant program of Coimbra University Hospitals. METHODS: Between November 2003 aid December 2008, 132 patients were transplanted, with a mean age of 52.0 years (range 3-71 years), of whom 98 were male (74%). Half of the patients had dilated cardiomyopathy and 33% ischemic cardiomyopathy. The mean age of donors was 31.7 years and 102 we...
Long-term follow-up of elderly patients subjected to aortic valve replacement w...
Coutinho, GF; Pancas, R; Antunes, PE; Antunes, MJWe propose to analyse the long-term follow-up in patients older than 65 years of age who received a mechanical valve in the aortic position, using death and prosthetic-related complications as endpoints. From April 1988 to December 1995, 144 consecutive patients 65-75 years of age (mean 67.7+/-2.5) were enrolled. Total duration of follow-up was 1663 patient-years (median 13.0 years) and was complete for 99% of ...
Donor mitral valve repair in cardiac transplantation
Prieto, D; Antunes, PE; Antunes, MJINTRODUCTION: For many patients suffering from end-stage heart failure, heart transplantation remains the only hope for survival, but the shortage of donor organ is increasing. The growing number of patients awaiting heart transplantation has led many centers to expand the donor pool by liberalizing donor criteria, including advances in surgical techniques on the donor heart, such as valve repair. PATIENTS AND ...
Risk-prediction for postoperative major morbidity in coronary surgery
Antunes, PE; Oliveira, JF; Antunes, MJOBJECTIVE: Analysis of major perioperative morbidity has become an important factor in assessment of quality of patient care. We have conducted a prospective study of a large population of patients undergoing coronary artery bypass surgery (CABG), to identify preoperative risk factors and to develop and validate risk-prediction models for peri- and postoperative morbidity. METHODS: Data on 4567 patients who und...