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Long-term predictive accuracy of the ‘mild cognitive impairment due to Alzheime...

Cardoso, Sandra; Montalvo, Alexandre; Maroco, João; Silva, Dina; Alves, Luísa; Guerreiro, Manuela; Mendonça, Alexandre de

Background: The development and clinical use of biomarkers has dramatically changed the framework of Alzheimer’s disease (AD) management, allowing the diagnosis at the mild cognitive impairment (MCI) stage. In 2015 we compared the prevalence and prognosis of AD at the MCI stage according to different criteria available at that time, and we found that the National Institute of Aging-Alzheimer Association (NIA-AA...


Frequency, sociodemographic, and neuropsychological features of patients with s...

Pestana, Pedro Câmara; Cardoso, Sandra; Guerreiro, Manuela; Maroco, João; Jessen, Frank; Couto, Frederico Simões do; Mendonça, Alexandre de

Background: Subjective Cognitive Decline (SCD) is recognized as a risk stage for future cognitive impairment and dementia. The criteria for SCD include normal performance on neuropsychological testing; however, there is a lack of consensus regarding standard score cut-offs for neuropsychological tests to define cognitive impairment and to differentiate between SCD and Mild Cognitive Impairment (MCI). This study...


Bem-estar dos Professores e a sua relação na Atividade Pedagógica no 1.º CEB

Cardoso, Sandra

O bem-estar dos professores é influenciado por fatores como a satisfação na vida, a felicidade pessoal, e o funcionamento psicológico positivo. Os professores são capazes de demonstrar o funcionamento psicológico positivo quando têm a capacidade de construir bons relacionamentos interpessoais, desenvolvendo competências de autonomia e de crescimento pessoal potenciando as experiências vividas na escola e influe...


Frequency, sociodemographic, and neuropsychological features of patients with s...

Câmara Pestana, Pedro; Cardoso, Sandra; Guerreiro, Manuela; Marôco, João; Jessen, Frank; Simões Do Couto, Frederico; De Mendonça, Alexandre

Background: Subjective Cognitive Decline (SCD) is recognized as a risk stage for future cognitive impairment and dementia. The criteria for SCD include normal performance on neuropsychological testing; however, there is a lack of consensus regarding standard score cut-offs for neuropsychological tests to define cognitive impairment and to differentiate between SCD and Mild Cognitive Impairment (MCI). This study...


Impact of neuropsychological assessment on subjective memory complaints in pati...

Anjos, Ricardo; Madruga, Nuno; Cardoso, Sandra; Schmand, Ben; Guerreiro, Manuela; De Mendonça, Alexandre; Ribeiro, Filipa

Introduction: Patients with Alzheimer's disease (AD), namely at an initial stage like amnestic cognitive impairment (aMCI), typically present with memory complaints. They also have difficulties regarding self-knowledge about their cognitive deficits. In clinical practice, a formal neuropsychological assessment is often done. The present study aimed to understand whether patients with aMCI retain the ability to ...


Amyloid-negative, neurodegeneration-negative amnestic mild cognitive impairment

Cardoso, Sandra; Guerreiro, Manuela; Montalvo, Alexandre; Silva, Dina; Alves, Luísa; Mendonça, Alexandre de

Background:The concept of amnestic mild cognitive impairment (aMCI) was developed to identify patients at an initial stage of Alzheimer's disease (AD). However, some patients with aMCI do not present biomarkers of amyloid pathology or neuronal injury.Objective:To know the natural history of amyloid-negative and neurodegeneration-negative patients with aMCI, namely to ascertain: 1) whether these patients remain ...


Different MMSE domains are associated to cognitive decline and education

Cardoso, Sandra; Barros, Ricardo; Maroco, J. P.; Mendonça, Alexandre de; Guerreiro, Manuela

The Mini-Mental State Examination (MMSE) is a long-established test to screen for dementia, estimate the severity and monitor the progression of cognitive impairment. The MMSE total score is dependent upon demographic factors, particularly education, but little is known about how education influences the 6 distinct MMSE cognitive domains. The present study aims to understand how the performances in the MMSE cog...


Time perspective and amnestic mild cognitive impairment

Coelho, Sara; Mendonça, Alexandre; Marôco, J. P.; Cardoso, Sandra; Mello, Zena; Guerreiro, Manuela

Objective. We examined time perspective in patients with amnesic mild cognitive impairment (aMCI). Prior research has shown that aMCI is associated with difficulties in experiencing time duration and succession. However, this line of inquiry has not been extended to time perspective. We examined associations between aMCI and multiple dimensions of time perspective including perceived orientations and relationsh...


Different MMSE domains are associated to cognitive decline and education

Cardoso, Sandra; Barros, Ricardo; Marôco, João; De Mendonça, Alexandre; Guerreiro, Manuela

The Mini-Mental State Examination (MMSE) is a long-established test to screen for dementia, estimate the severity and monitor the progression of cognitive impairment. The MMSE total score is dependent upon demographic factors, particularly education, but little is known about how education influences the 6 distinct MMSE cognitive domains. The present study aims to understand how the performances in the MMSE cog...


The update of semantic memories in amnestic mild cognitive impairment

Mendonça, Alexandre De; Cardoso, Sandra; Marôco, J. P.; Guerreiro, Manuela; Carmo, Joana C

It is still controversial to what extent neocortical consolidated memories are susceptible of change by processes of reconsolidation and transformation throughout experience, and whether the medial temporal lobes are necessary for this update of semantic consolidated memories, as they are for episodic remembering. We hypothesize that patients with amnestic mild cognitive impairment (aMCI) who have deficits in e...


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