8 documents found, page 1 of 1
Effects of nitric oxide inhibitors in mice with bladder outlet obstruction
Pereira,Marcy Lancia; D’ancona,Carlos Arturo Levi; Rojas-Moscoso,Julio Alejandro; Ramos Filho,Antonio Celso Saragossa; Mónica,Fabiola ZakiaABSTRACT Purpose To investigate the lower urinary tract changes in mice treated with L-NAME, a non-selective competitive inhibitor of nitric oxide synthase (NOS), or aminoguanidine, a competitive inhibitor of inducible nitric oxide synthase (iNOS), after 5 weeks of partial bladder outlet obstruction (BOO), in order to evaluate the role of constitutive and non-constitutive NOS in the pathogenesis of this experim...
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in ...
Leite,Camila Ferreira; Marangoni,Fábio André; Camargo,Enilton Aparecido; Braga,Angélica de Fátima de Assunção; Toro,Ivan Felizardo ContreraPURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of...
Effect of acute administration of sildenafil to rats with detrusor overactivity...
Reges,Ricardo; D'ancona,Carlos; Monica,Fabiola; Antunes,EdsonPurpose Recently, the effect of phosphodiesterase inhibitors (PDE5i) in the lower urinary tract symptoms (LUTS) associated to benign prostatic hyperplasia have been studied thoroughly. However, it remains unclear how the PDE5i improve LUTS. Therefore, the aim of the present study was to evaluate the potential of acute administration of the PDE5i sildenafil to improve detrusor overactivity (DO) induced by Nω-nit...
Interação entre as vias de sinalização de receptores serotoninérgicos e Β-adren...
Delbin,Maria Andréia; Silva,Alexandre Sérgio; Antunes,Edson; Zanesco,AngelinaFUNDAMENTO: A doença coronária tem sido amplamente estudada em pesquisas cardiovasculares. No entanto, pacientes com doença arterial periférica (DAP) têm piores resultados em comparação àqueles com doença arterial coronariana. Portanto, os estudos farmacológicos com artéria femoral são altamente relevantes para a melhor compreensão das respostas clínicas e fisiopatológicas da DAP. OBJETIVO: Avaliar as proprieda...
Standardization of a method of prolonged thoracic surgery and mechanical ventil...
Leite,Camila Ferreira; Toro,Ivan Felizardo Contrera; Antunes,Edson; Mussi,Ricardo KalafPurpose: To evaluate the immediate pulmonary and systemic inflammatory response after a long-term operative period. Methods: Wistar rats in the experimental group were anaesthetized and submitted to tracheostomy, thoracotomy and remained on mechanical ventilation during three hours. Control animals were not submitted to the operative protocol. The following parameters have been evaluated: pulmonary myeloperoxid...
Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ...
Oliveira,Fernando José de; Vieira,Reinaldo Wilson; Coelho,Otávio Rizzi; Petrucci,Orlando; Oliveira,Pedro Paulo Martins de; Antunes,NilsonOBJETIVO: Processos inflamatórios e infecciosos mediados por bactérias em sítios distantes têm sido descritos como fator de risco à doença coronariana isquêmica aguda (DCIA). MÉTODOS: Cento e oitenta e um pacientes com DCIA, com e sem periodontites crônicas, foram incluídos neste estudo. Os pacientes foram admitidos no HC da UNICAMP e estratificados em três grupos: grupo 1 - pacientes com periodontite crônica g...
Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide defi...
D'Ancona,Carlos Arturo Levi; Mónica,Fabíola Zakia Taufic; Reges,Ricardo; Cohen,David; Silva,Fabio Henrique da; Nucci,Gilberto De; Antunes,EdsonABSTRACT Objective: to evaluate the protective effects of BAY 41-2272, a soluble guanylate cyclase activator, on changes in cystometric parameters in rats deficient in nitric oxide (NO). Methods: Rats were divided into the following groups: (a) control; (b) DMSO; (c) L-NAME; (d) BAY 41-2272 alone; (e) L-NAME + BAY 41-2272. The NO synthase blocker L-NAME (20 mg/rat/day) was given in drinking water concomitantly ...
Papel do exercício físico na isquemia/reperfusão pulmonar e resposta inflamatória
Delbin,Maria Andréia; Antunes,Edson; Zanesco,AngelinaO avanço tecnológico associado aos novos conhecimentos científicos tem proporcionado melhora na prevenção e/ou tratamento das complicações cardiorrespiratórias advindas de cirurgias cardiotorácicas e procedimentos envolvendo isquemia/reperfusão (IR), mas os riscos destes procedimentos ainda permanecem altos. Assim, medidas profiláticas que possam reduzir o aparecimento das complicações pós-cirúrgicas em pacient...