19 documents found, page 1 of 2
Bullous pemphigoid
Miyamoto,Denise; Santi,Claudia Giuli; Aoki,Valéria; Maruta,Celina WakisakaAbstract: Bullous pemphigoid is the most frequent autoimmune bullous disease and mainly affects elderly individuals. Increase in incidence rates in the past decades has been attributed to population aging, drug-induced cases and improvement in the diagnosis of the nonbullous presentations of the disease. A dysregulated T cell immune response and synthesis of IgG and IgE autoantibodies against hemidesmosomal pro...
Diagnostic approach of eosinophilic spongiosis,
Morais,Karina Lopes; Miyamoto,Denise; Maruta,Celina Wakisaka; Aoki,ValériaAbstract Eosinophilic spongiosis is a histological feature shared by some distinct inflammatory disorders, and is characterized by the presence of intraepidermal eosinophils associated with spongiosis. Most often, isolated eosinophilic spongiosis indicates the early stages of a subjacent autoimmune bullous dermatosis, such as the pemphigus group and bullous pemphigoid. Herein, the main causes of eosinophilic sp...
Fogo selvagem: endemic pemphigus foliaceus
Hans-Filho,Günter; Aoki,Valéria; Bittner,Nelise Ritter Hans; Bittner,Guilherme CanhoAbstract: Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, ...
Skin barrier in atopic dermatitis: beyond filaggrin
Zaniboni,Mariana Colombini; Samorano,Luciana Paula; Orfali,Raquel Leão; Aoki,ValériaAbstract: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical ...
Immunofluorescence testing in the diagnosis of autoimmune blistering diseases: ...
Arbache,Samia Trigo; Nogueira,Tarsila Gasparotto; Delgado,Lívia; Miyamoto,Denise; Aoki,ValériaBACKGROUND: Immunofluorescence testing is an important tool for diagnosing blistering diseases. OBJECTIVE: To characterize the immunofluorescence findings in patients diagnosed with autoimmune blistering skin diseases. METHODS: We retrospectively analyzed immunofluorescence results encompassing a 10-year period. RESULTS: 421 patients were included and divided into 2 groups: group 1- intraepidermal blistering di...
Linear IgA bullous dermatosis: report of an exuberant case
Souza,Beatriz Cavalcanti de; Fregonesi,Nádire Cristina Freire Pontes; Tebcherani,Antônio José; Sanchez,Ana Paula Galli; Aoki,ValériaLinear immunoglobulin A dermatosis is a rare autoimmune bullous disease, but the most common autoimmune bullous dermatosis in children. We report a typical exuberant case of linear IgA dermatosis in a ten-month old child, who showed good response to treatment with corticosteroids and dapsone.
Atopic dermatitis in adults: clinical and epidemiological considerations
Orfali,Raquel Leão; Shimizu,Marta M.; Takaoka,Roberto; Zaniboni,Mariana C.; Ishizaki,Aline S.; Costa,Anderson A.; Tiba,Ana Paula L.; Sato,Maria NotomiOBJECTIVE: Atopic dermatitis (AD) is a chronic inflammatory disease causing intense pruritus, and with typical clinical features. There are few epidemiological studies concerning AD in adults, as well as little information about its prognostic. The aim of this study was to evaluate the clinical and epidemiological course of adults with AD. METHODS: 80 patients aged above 18 years (mean age = 29 years) were sele...
Penfigoide bolhoso no adulto mais jovem: relato de três casos
Zanella,Roberta Richter; Xavier,Tamar Alencar; Tebcherani,Antônio José; Aoki,Valéria; Sanchez,Ana Paula GalliO penfigoide bolhoso é uma dermatose bolhosa autoimune subepidérmica, mais comumente observada na população idosa (acima dos 70 anos). Autoanticorpos são formados contra antígenos específicos da zona de membrana basal: BP180 e BP230 (proteínas do hemidesmossomo). Apresentamos três casos de penfigoide bolhoso, em adultos com menos de 50 anos de idade, destacan do as peculiaridades clínicas na faixa etária mais j...
Imunofluorescência direta e indireta
Aoki,Valéria; Sousa Jr,Joaquim X.; Fukumori,Lígia M. I.; Périgo,Alexandre M.; Freitas,Elder L.; Oliveira,Zilda N. P.A imunofluorescência é um valioso instrumento auxiliar no diagnóstico das dermatoses bolhosas autoimunes e desordens inflamatórias, uma vez que seus achados clínicos e histopatológicos podem não ser determinantes. Consiste em um método laboratorial factível, que requer profissionais técnicos experientes, e detecta imunocomplexos in situ e/ou circulantes, que podem estar envolvidos na patogênese de tais enfermid...
Estudo da imunofluorescência direta, imunomapeamento e microscopia ótica na por...
Vieira,Fátima Mendonça Jorge; Aoki,Valéria; Oliveira,Zilda Najjar Prado de; Martins,José Eduardo CostaFUNDAMENTO: Apesar de a porfiria cutânea tardia ser a mais frequente das porfirias, há poucos estudos que abordam sua fisiopatologia cutânea. OBJETIVO: Avaliar as alterações cutâneas na porfiria cutânea tardia utilizando a microscopia ótica e a imunofluorescência direta, antes e depois do tratamento com cloroquina. Realizar o imunomapeamento antigênico da bolha para estudo do seu nível de clivagem. MÉTODOS: Rel...