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Longitudinal assessment of migraine burden in resistant and refractory migraine...

Pensato, Umberto; Ornello, Raffaele; Rosignoli, Chiara; Caponnetto, Valeria; Onofri, Agnese; Braschinsky, Mark; Sved, Olga; Gil-Gouveia, Raquel

Background: Some individuals with migraine fail to respond adequately to preventive treatments, bearing most of migraine burden. The European Headache Federation (EHF) classifies these individuals into resistant migraine (ResM) or refractory migraine (RefM) according to treatment failures, debilitating headache days, and disease duration. We investigated the evolution of these categories over six months in pati...


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