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Global age-sex-specific mortality, life expectancy, and population estimates in...

Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, S

Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...


Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2...

Haeuser, E; Serfes, AL; Cork, MA; Yang, M; Abbastabar, H; Abhilash, ES; Adabi, M; Adebayo, OM; Adekanmbi, V; Adeyinka, DA; Afzal, S; Ahinkorah, BO

Background: Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is...


The overlapping burden of the three leading causes of disability and death in s...

Reiner, RC; Welgan, CA; Troeger, CE; Baumann, MM; Weiss, DJ; Deshpande, A; Blacker, BF; Miller Petrie, MK; Earl, L; Bhatt, S; Abolhassani, H

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their com...


Subnational mapping of HIV incidence and mortality among individuals aged 15–49...

Sartorius, B; VanderHeide, JD; Yang, M; Goosmann, EA; Hon, J; Haeuser, E; Cork, MA; Perkins, S; Jahagirdar, D; Schaeffer, LE; Serfes, AL; LeGrand, KE

Background. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we devel...


Conifers phytochemicals: A valuable forest with therapeutic potential

Bhardwaj, K; Silva, AS; Atanassova, M; Sharma, R; Nepovimova, E; Musilek, K; Sharma, R; Alghuthaymi, MA; Dhanjal, DS; Nicoletti, M; Sharma, B

Conifers have long been recognized for their therapeutic potential in different disorders. Alkaloids, terpenes and polyphenols are the most abundant naturally occurring phytochemicals in these plants. Here, we provide an overview of the phytochemistry and related commercial products obtained from conifers. The pharmacological actions of different phytochemicals present in conifers against bacterial and fungal i...


Mapping subnational HIV mortality in six Latin American countries with incomple...

Cork, MA; Henry, NJ; Watson, S; Croneberger, AJ; Baumann, M; Letourneau, ID; Yang, M; Serfes, AL; Abbas, J; Abbasi, N; Abbastabar, H; Abreu, LG

Background: Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. This paucity is partially due to incomplete vital registration (VR) systems and statistical challenges related to estimating mortality rates in areas w...


Anemia prevalence in women of reproductive age in low- and middle-income countr...

Kinyoki, D; Osgood-Zimmerman, AE; Bhattacharjee, NV; Schaeffer, LE; Lazzar-Atwood, A; Lu, D; Ewald, SB; Donkers, KM; Letourneau, ID; Collison, M

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Addi...


Mapping inequalities in exclusive breastfeeding in low- and middle-income count...

Bhattacharjee, NV; Schaeffer, LE; Hay, SI; Lu, D; Schipp, MF; Lazzar-Atwood, A; Donkers, KM; Abady, GG; Abd-Allah, F; Abdelalim, A; Abebo, ZH

Exclusive breastfeeding (EBF)-giving infants only breast-milk for the first 6 months of life-is a component of optimal breastfeeding practices effective in preventing child morbidity and mortality. EBF practices are known to vary by population and comparable subnational estimates of prevalence and progress across low- and middle-income countries (LMICs) are required for planning policy and interventions. Here w...


Estimating global injuries morbidity and mortality: methods and data used in th...

James, SL; Castle, CD; Dingels, ZV; Fox, JT; Hamilton, EB; Liu, Z; Roberts, NLS; Sylte, DO; Bertolacci, GJ; Cunningham, M; Henry, NJ; LeGrand, KE

Background. While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of g...


Global injury morbidity and mortality from 1990 to 2017: results from the Globa...

James, SL; Castle, CD; Dingels, ZV; Fox, JT; Hamilton, EB; Liu, Z; S, Roberts, NL; Sylte, DO; Henry, NJ; LeGrand, KE; Abdelalim, A; Abdoli, A

Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and year...


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