A transição nutricional tem afetado grande parte dos países emergentes, devido às mudanças socioeconômicas. Os perfis dietéticos hipoproteico e hiperlipídico têm caracterizado o consumo alimentar de populações carentes. Diante disso, o SNC apresenta sensibilidade notória aos diferentes perfis nutricionais, resultando em mudanças nas suas funções estruturais e cognitivas. O objetivo do estudo foi avaliar o efeit...
Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality of life. In developing countries, like in Brazil, in poor settings, dietary habits, traditionally hypoproteic, are changing rapidly to western-type high-fat foods. These rapidly changing dietary habits are imposing new challenges to human health and there are many questions in the field that remain to be answered. ...
Ectodermal dysplasia (ED) is a genetically heterogeneous condition resulting from clinical anomalies of structures derived from the ectoderm, such as the hair, nails, sweat glands, and teeth. This clinical report presents the case of a child diagnosed with hypohidrotic ED at 2 years of age; clinical and imaging evaluation was performed with 6-year follow-up, and we present details of the prosthetic dental care,...
Cancer is a disease that originates through genomic alterations that occur by defects in the systematic process of cell injury and repair. 5-fluorouracil (5-FU) is one of the most used anti-neoplastic drugs in the cancer treatment, exerting multiple effects on abnormal cell growth. 5-FU treatment affects rapidly proliferating tissues, causing mucositis, anorexia, nausea, vomiting and diarrhea. Natural Killer (N...
Apolipoprotein E (APOE=gene, apoE=protein) is a known factor regulating the inflammatory response that may have regenerative effects during tissue recovery from injury. We investigated whether apoE deficiency reduces the healing effect of alanyl-glutamine (Ala-Gln) treatment, a recognized gut-trophic nutrient, during tissue recovery after 5-FU-induced intestinal mucositis. APOE-knockout (APOE-/-) and wild-type ...