6 documents found, page 1 of 1
Subcutaneous immunotherapy with aeroallergens - evaluation of adherence in real...
Lourenço, Tatiana; Fernandes, Mara; Lopes, Anabela; Pedro, ElisaIntroduction. Adherence in allergen immunotherapy is crucial for its efficacy. At least 3 years of treatment are recommended for achieving a long-term modifying effect. Objectives. To assess patient’s adherence and to identify determinant factors for allergen subcutaneous immunotherapy (SCIT) suspension in patients with respiratory allergy. Methods. Retrospective analysis of the medical record of patients submi...
Chlorhexidine: a hidden life-threatening allergen
Fernandes, Mara; Lourenço, Tatiana; Lopes, Anabela; Spínola Santos, Amélia; Pereira Santos, Maria Conceição; Pereira Barbosa, ManuelChlorhexidine is a commonly used antiseptic and disinfectant in the health-care setting. Anaphylaxis to chlorhexidine is a rare but potentially life-threatening complication. Epidemiologic data suggest that the cases of chlorhexidine allergy appears to be increasing. In this article we report a life-threatening anaphylactic shock with cardiorespiratory arrest, during urethral catheterization due to chlorhexidin...
Contribution of molecular diagnosis to bee venom allergic patients with systemi...
Lourenço, Tatiana; Fernandes, Mara; Lopes, Anabela; Pedro, Elisa; Barbosa, Manuel Pereira; Santos, M. Conceição PereiraIntroduction: Bee venom (BV) allergy is one of the most common causes of severe anaphylaxis. Venom immunotherapy (VIT) is considered the most effective treatment, but systemic reactions may occur. This study aimed to characterize the sensitization profile by molecular components of patients with BV anaphylaxis under VIT and to evaluate whether systemic reactions during the build-up phase of VIT protocol are rel...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Lopes, Maria CelesteThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Celeste Lopes, MariaThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...
Xavier-Magalhães, Ana; Oliveira, Ana Isabel Ferreira; de Castro, Joana Vieira; Pojo, Marta; Gonçalves, Céline S.; Lourenço, TatianaAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...