10 documents found, page 1 of 1
Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
Caracterização fitoquímica e atividade antibacteriana do extrato etanólico e do...
Santos, Damires Inácio dos; Sousa Júnior, Dárcio Luiz de; Monteiro, Maria de Fátima Guedes; Aquino, Pedro Everson Alexandre deCymbopogon citratus is a well known and used vegetable, belonging to the Paeceae family, originated in Asia and in some tropical countries, popularly known as Capim-santo is effective against various pathologies such as asthma, insomnia, colic and anxiety. The present study aimed to determine the phytochemical profile of the ethanolic extract and essential oil from C. citratus leaves, as well as the antibacteri...
Atividade antibacteriana e moduladora do óleo essencial de Allium sativum L. (A...
Silva, Álife Diêgo Lima; Monteiro, Maria de Fátima Guedes; Sousa Júnior, Dárcio Luiz de; Macêdo, Nair Silva Macêdo; Saraiva, Cícero Roberto NascimentoThe present study aims to evaluate the antibacterial and modulating activity of the essential oil of Allium sativum L. (OEAs) associated with LED lights. The essential oil was obtained by hydrodistillation and the antibacterial and modulating activity was performed by the gas contact method with the use of yellow, blue and red LED light along with the antibiotics amikacin, ciprofloxacin, gentamicin, norfloxacin...
Avaliação do efeito anticonvulsivante neuroprotetor de N-metil-(2S,4R)-trans-4-...
Aquino, Pedro Everson Alexandre deEpilepsy is a chronic neurological disease characterized by recurrent seizures, resulting from excessive neuronal discharges. Considering that inflammatory processes and oxidative stress are related to their pathogenesis, we investigated the possible anticonvulsant effects of a derivative of the amino acid proline from Sideroxylon obtusifolium, (also known as quixaba, black quixaba, sapoteiaba, hawthorn, corone...
Bacteriological analysis of water used for human consumption at Sítio Bela Vist...
Saraiva, Maria Danyelle Coêlho; Paixão, Letícia Araújo da; Silva, Maryna Araújo da; Fernandes, Morgana Braga; Silva, Thaylon Menezes Ferreira daThe study aimed to carry out bacteriological analysis of the water used for human consumption at Sítio Bela Vista in the city of Barbalha, Ceará, to evaluate the presence of total coliforms and Escherichia coli in the samples, as well as the hygienic-sanitary conditions close to the spring. Three collections were made in sterile borosilicate glass flasks with an interval of eight days between them, from the spr...
The medicinal species Myracrodruon urundeuva Fr. All. presents antidiabetic and...
Moreira, Alisson Cordeiro; Moreira, Ítalo Cordeiro; Alves, Viviane de Jesus; Carvalho, José Bégue Moreira; Lopes, Maria Janice PereiraThe Type 2 diabetes (T2D) is a global epidemics and considered as an inflammation related disease. Myracrodruon urundeuva (Anacardiaceae) is used in Northeast Brazil, because of its anti-inflammatory properties. The species is known to present tannins and chalcones among its active compounds. The objectives of the work were to investigate the antidiabetic and hypolipidemic activities of the stem bark decoction ...
The treadmill exercise protects against dopaminergic neuron loss and brain oxid...
Costa, Roberta Oliveira da; Gadelha-Filho, Carlos Vinicius Jataí; Costa, Ayane Edwiges Moura da; Feitosa, Mariana Lima; Araújo, Dayane Pessoa deParkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. ...
The anti-inflammatory effects of N-methyl-(2S,4R)- trans -4-hydroxy- l -proline...
Aquino, Pedro Everson Alexandre de; Magalhães, Talita Rocha; Nicolau, Lucas Antonio Duarte; Leal, Luzia Kalyne Almeida MoreiraBackground Sideroxylon obtusifolium (Roem. & Schult.) T.D. Penn., Sapotaceae family, is a medicinal species native to the Brazilian Northeastern region. The plant is popularly used as an anti-inflammatory and hypoglycemic. Purpose To evaluate the anti-inflammatory properties of the N-methyl-(2S,4R)-trans-4-hydroxy-l-proline (NMP) from S. obtusifolium leaves in models of inflammation and to clarify its action me...
Atividade anti-inflamatória e antinociceptiva da N-Metil-Trans-4-Hidroxi-L-Prol...
Aquino, Pedro Everson Alexandre deSideroxylum obtusifolium (Humb. Ex. Roem. & Schult) T. B. Penn (Sapotaceae) of common occurrence in South America, is known in the Northeast of Brazil as "Quixabeira". The decoctions from the stem bark and leaves are used in folk medicine as anti-inflammatory. The present study evaluated by in vitro and in vivo models the anti-inflammatory and antinociceptive effects of the compound N-methyl-trans-4-hydroxy-L-p...
Efeito antibacteriano e antifúngico de extratos etanólico, hexânico e metanólic...
Santana, Paloma de Souza; Andreza, Raul Sousa; Leite, Vivianne Inácio; Sousa, Priscila Caracas Vieira de; Alves, Amanda Aragão; Tintino, Saulo RelisonThe infections caused by bacteria and fungi, as well as the subsequent resistance of these microorganisms continue with high incidencesthus studies of medicinal plants and their combination with conventional therapy, are becoming essential. This study examined the antibacterial, antifungal and modifier of resistance to antibiotics and antifungal extracts of ethanol, hexane and methanol from the leaves of Kalanc...