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Preliminary in vitro evaluation of the anti-proliferative activity of guanylhyd...
França, Paulo H. B.; Silva-Júnior, Edeildo F. da; Aquino, Pedro G. V.; Santana, Antônio E. G.; Ferro, Jamylle N. S.; Barreto, Emiliano de OliveiraGuanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibiti...
Date: 2016
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Origin: Oasisbr