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Novel ocellatin peptides mitigate LPS-induced ROS formation and NF-kB activatio...
Sousa, Nayara A.; Oliveira, Guilherme A. L.; de Oliveira, Ana Patrícia; Lopes, André Luís F.; Iles, Bruno; Nogueira, Kerolayne M.; Araújo, Thiago S. L.Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with potential for biotechnological applications. Therefore, this study aimed to determine the primary structure and investigate peptides obtained from the cutaneous secretions of the amphibian, Leptodactylus vastus, as a source of bioactive molecules. The peptides obtained possessed the amino acid sequences, GVVDILKGAAKDLAGH and GVV...
Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct...
Gomes, Bruno S.; S. Neto, Benedito P.; Lopes, Everton M.; Cunha, Francisco V. M.; Araújo, Alyne R.; Wanderley, Carlos W. S.; Wong, Deysi V. T.Myrtenol is a bicyclic monoterpene with anti-in fl ammatory properties. However, the mechanisms involved are partially unknown. Here, we investigated the effect of myrtenol during experimental chronic arthritis and the possible modulating activity of oxidative stress and neutrophil migration. Complete Freund's Adjuvant (CFA)-sensitized rats were treated with vehicle (1 mL/kg, po), myrtenol (12.5, 25 or 50 mg/kg...