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The unseen ingredients: a systematic review of the prevalence of microplastics ...

Background: Plastics have revolutionized every aspect of modern life [1, 2], offering convenience but also bringing forth environmental and health hazards. Their exponential production and improper disposal have led to the global burden of microplastics (MPs) and nanoplastics (NPs) in the environment [3, 4]. These tiny particles possess the alarming ability to infiltrate the food chain, thereby posing a potenti...

Early pathways of toxicity triggered by 3,4-methylenedioxypyrovalerone unveiled...

Toxicometabolomics: small molecules to answer big toxicological questions

Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metab...

In vitro volatile exometabolome signature of clear cell renal cell carcinoma

A translational in vitro and in vivo metabolomics study reveals altered hepatic...

Toxicometabolomic insights into the mechanisms of hepatotoxicity triggered by a...

3,4-Methylenedioxymethamphetamine hepatotoxicity under the heat stress conditio...

Hyperthermia has been extensively reported as a life-threatening consequence of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) abuse. In this work, we used a sensitive untargeted metabolomic approach based on gas chromatography-mass spectrometry to evaluate the impact of hyperthermia on the hepatic metabolic changes caused by MDMA. For this purpose, primary mouse hepatocytes were exposed to subtoxic (LC01 an...

In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in m...

3,4-Methylenedioxypyrovalerone (MDPV) is consumed worldwide, despite its potential to cause toxicity in several organs and even death. There is a recognized need to clarify the biological pathways through which MDPV elicits general and target-organ toxicity. In this work, a comprehensive untargeted GC-MS-based metabolomics analysis was performed, aiming to detect metabolic changes in putative target organs (bra...

Volatilomics reveals potential biomarkers for identification of renal cell carc...

The identification of noninvasive biomarkers able to detect renal cell carcinoma (RCC) at an early stage remains an unmet clinical need. The recognition that altered metabolism is a core hallmark of cancer boosted metabolomic studies focused in the search for cancer biomarkers. The present work aims to evaluate the performance of the volatile metabolites present in the extracellular medium to discriminate RCC c...

Effect of temperature on 3,4-Methylenedioxypyrovalerone (MDPV)-induced metabolo...

3,4-Methylenedioxypyrovalerone (MDPV) is one of the most popular cathinone derivatives worldwide and has recently been associated with several intoxications and deaths, in which, similarly to amphetamines, hyperthermia appears to play a prominent role. However, there remains a huge information gap underlying the mechanisms associated with its hepatotoxicity, namely under hyperthermic conditions. Here, we use a ...