Encontrados 8 documentos, a visualizar página 1 de 1
Valorização da cortiça orientada para a inovação e sustentabilidade
Fernandes, Emanuel Mouta; Araújo, Ana Rita Rodrigues; Pires, Ricardo A.; Reis, R. L.Num mundo em rápida transformação, onde os desafios de mitigação do impacto ambiental e a gestão eficiente dos subprodutos aumentam, observa-se um crescente interesse pelo desenvolvimento de produtos de base natural. É neste contexto que a cortiça ganha destaque pela sua capacidade de ser, simultaneamente, um recurso natural, renovável e essencial para a promoção da economia circular. A sua produção responsável...
Nanoengineered self-assembling peptides with increased proteolytic stability pr...
Castro, Vânia Isabel Baptista; Araújo, Ana Rita Rodrigues; Reis, R. L.; Pashkuleva, I.; Pires, R. A.The copper complex of the tripeptide glycineâ histidineâ lysine (GHK) has proven benefits in wound healing and tissue remodeling by promoting blood vessel growth and increasing skin oxygen levels, but its activity is reduced in body fluids due to fast proteolytic cleavage. Herein, we designed several peptides that bear the GHK sequence and can self-assemble into supramolecular nanostructures aiming for enhanced...
Glycopeptide-based supramolecular hydrogels induce differentiation of adipose s...
Castro, Vânia Isabel Baptista; Araújo, Ana Rita Rodrigues; Duarte, Filipa; Sousa-Franco, António; Reis, R. L.; Pashkuleva, I.; Pires, R. A.We applied a bottom-up approach to develop biofunctional supramolecular hydrogels from an aromatic glycodipeptide. The self-assembly of the glycopeptide was induced by either temperature manipulation (heatingâ cooling cycle) or solvent (DMSO to water) switch. The solâ gel transition was salt-triggered in cell culture media and resulted in gels with the same chemical compositions but different mechanical propert...
Functional gallic acid-based dendrimers as synthetic nanotools to remodel amylo...
Araújo, Ana Rita Rodrigues; Correa, Juan; Domínguez-Arca, Vicente; Reis, R. L.; Fernandez-Megia, Eduardo; Pires, R. A.The self-assembly of amyloid-β (Aβ) generates cytotoxic oligomers linked to the onset and progression of Alzheimer’s disease (AD). As many fundamental molecular pathways that control Aβ aggregation are yet to be unraveled, an important strategy to control Aβ cytotoxicity is the development of bioactive synthetic nanotools capable of interacting with the heterogeneous ensemble of Aβ species and remodel them into...
Vescalagin and castalagin present bactericidal activity toward methicillin-resi...
Araújo, Ana Rita Rodrigues; Araújo, Ana C.; Reis, R. L.; Pires, R. A.Polyphenols have been extensively exploited in the biomedical field because of their wide range of bioactive properties and historical use as traditional medicines. They typically present antioxidant, antimicrobial, antiamyloidogenic, and/or antitumor activities. In particular, cork water extracts and their components, have been previously reported to present antioxidant and antiamyloidogenic properties. On the...
Novel cork-based compounds for biomedical applications: from antibacterials to ...
Araújo, Ana Rita RodriguesPolyphenols are extensively studied due to their wide range of bioactivities. In this thesis we used this knowledge to evaluate a series of cork-based polyphenols/extracts to act: as anti-bacterial agents (Chapter 3); in the reduction of UV-mediated toxicity (Chapter 4); and as modulators of amyloid-b (Ab) aggregation/cytotoxicity (hallmark of Alzheimer’s disease, AD, Chapter 5). We found that vescalagin/castal...
Vescalagin and castalagin reduce the toxicity of amyloid-beta42 oligomers throu...
Araújo, Ana Rita Rodrigues; Camero, Sérgio; Taboada, Pablo; Reis, R. L.; Pires, R. A.The isomers vescalagin and castalagin protect SH-SY5Y cells from Aβ42-mediated death. This is achieved better by vescalagin due to the spatial organization of its OH group at the C1 position of the glycosidic chain, improving its capacity to remodel the secondary structure of toxic Aβ42 oligomers.
Cork: current technological developments and future perspectives for this natur...
Aroso, Ivo Manuel Ascensão; Araújo, Ana Rita Rodrigues; Pires, R. A.; Reis, R. L.Cork is the bark of Quercus suber L., the cork oak tree. It is currently explored for different industrial applications, of which stoppers for the wine industry is the most representative and economically important. During the processing stages, up to 30% of cork is transformed into powder, which is mainly used for energy production by the industry. This underexploited natural resource stream constitutes an opp...