6 documents found, page 1 of 1
Metformin reverses infertility in a mouse model of endometriosis: unveiling dis...
Neto, AC; Botelho, M; Rodrigues, AR; Lamas, S; Araújo, B; Guimarães, JT; Gouveia, AM; Almeida, H; Neves, D" Research question: Does metformin reverse endometriosis-associated infertility? Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformi...
Avaliação Endoscópica das Alterações da Deglutição em Idade Pediátrica: Experiê...
Nascimento, J; Moreira, I; Cunha, I; Forjaco, A; Alves, P; Ximenes Araújo, J; Pinto Sousa, J; Araújo, B; Sousa, H; Barros, EAs alterações da deglutição na criança afetam aproximadamente 1% das crianças/ano, nos Estados Unidos, sendo frequentemente subdiagnosticadas. O desenvolvimento de técnicas diagnósticas não invasivas tem permitido diagnósticos mais precisos, independentemente da idade. Este trabalho tem como objetivo identificar a prevalência das alterações da deglutição e a necessidade de avaliação instrumental por videofuoros...
Abcessos Subperiósteos como Complicação de Mastoidite Aguda em Idade Pediátrica...
Chantre, T; Barroso, M; Araújo, B; Oliveira, M; Sousa, H; Barros, EObjetivos: Comparação dos resultados cirúrgicos dos doentes submetidos a drenagem de Abcesso Subperiósteo (AS) face aos submetidos a mastoidectomia. Desenho de estudo: Observacional e retrospectivo. Material e Métodos: Revisão dos registos clínicos dos doentes em idade pediátrica com AS (n=56). Resultados: A incidência de AS tem-se mantido constante, com uma média de 2,5 casos/ ano. A drenagem de AS com miringo...
SARS-CoV-2 seroprevalence in healthcare workers: The experience of a Portuguese...
Ramos, A; Araújo, B; Lacerda, L; Flora, AL; Ribeiro, L; Patrício, E; Cardoso, MJ; Guimarães, JTBackground: Healthcare workers (HCW) are at increased risk of SARS-CoV-2 infection. Here, we describe the SARS-CoV-2 seroprevalence in HCW who work daily at a COVID-19 front-line hospital in Portugal. Methods: To this end, the seroprevalence of 1027 HCW, assessed after the peak of the first pandemic wave, was determined using the following immunoassays: Euroimmun Anti-SARS-CoV-2 ELISA IgG (Euroimmun, Luebeck, G...
Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVI...
Freitas, AT; Calhau, C; Antunes, G; Araújo, B; Bandeira, M; Barreira, S; Bazenga, F; Braz, S; Caldeira, D; Santos, SCR; Faria, A; Faria, D; Fraga, MVitamin D is a fundamental regulator of host defences by activating genes related to innate and adaptive immunity. Previous research shows a correlation between the levels of vitamin D in patients infected with SARS-CoV-2 and the degree of disease severity. This work investigates the impact of the genetic background related to vitamin D pathways on COVID-19 severity. For the first time, the Portuguese populatio...
Inhibition of the formation in vitro of putatively carcinogenic metabolites der...
Gouveia, MJ; Nogueira, V; Araújo, B; Gärtner, F; Vale, NInfections caused by Schistosoma haematobium and Opisthorchis viverrini are classified as carcinogenic. Although carcinogenesis might be a multifactorial process, it has been postulated that these helminth produce/excrete oxysterols and estrogen-like metabolites that might act as initiators of their infection-associated carcinogenesis. Current treatment and control of these infections rely on a single drug, pra...