7 documents found, page 1 of 1
An integrative sialomic analysis reveals molecules from Triatoma sordida (Hemip...
Praça, Yanna Reis; Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bastos, Izabela Marques Dourado; Bentes, Kaio Luís da SilvaTriatomines have evolved salivary glands that produce versatile molecules with various biological functions, including those leading their interactions with vertebrate hosts’ hemostatic and immunological systems. Here, using high-throughput transcriptomics and proteomics, we report the first sialome study on the synanthropic triatomine Triatoma sordida. As a result, 57,645,372 reads were assembled into 26,670 c...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the firs...
Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy ...
Morais Júnior, Gilberto Santos; Kurizky, Patricia Shu; Cerqueira, Selma Regina Penha Silva; Barroso, Daniel Holanda; Schulte, Heidi LuiseExperts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the fir...
Proteomic mapping of multifunctional complexes within Triatomine saliva
Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bentes, Kaio Luís da Silva; Bastos, Izabela Marques DouradoTriatomines are hematophagous insects that transmit Trypanosoma cruzi, the etiological agent of Chagas disease. This neglected tropical disease represents a global health issue as it is spreading worldwide. The saliva of Triatominae contains miscellaneous proteins crucial for blood feeding acquisition, counteracting host's hemostasis while performing vasodilatory, anti-platelet and anti-coagulant activities, be...
Triatomines : trypanosomatids, bacteria, and viruses potential vectors?
Vieira, Caroline Barreto; Praça, Yanna Reis; Bentes, Kaio Luís da Silva; Santiago, Paula Beatriz; Silva, Sofia Marcelino MartinsTriatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus Linshcosteus occur in India, and species belonging to the Triatom...
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yo...
Santiago, Paula Beatriz; Araújo, Carla Nunes de; Motta, Flávia Nader; Praça, Yanna Reis; Charneau, Sébastien; Bastos, Izabela Marques DouradoTicks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can transmit pathogenic microorganisms to the vertebrate host. Among the molecules related to the blood-feeding habit, proteases play an essential role. In this review,...
A Deep Insight into the Sialome of Rhodnius neglectus, a vector of chagas disease
Santiago, Paula Beatriz; Assumpção, Teresa Cristina França de; Araújo, Carla Nunes de; Bastos, Izabela Marques Dourado; Neves, DavidBackground Triatomines are hematophagous insects that act as vectors of Chagas disease. Rhodnius neglectus is one of these kissing bugs found, contributing to the transmission of this American trypanosomiasis. The saliva of hematophagous arthropods contains bioactive molecules responsible for counteracting host haemostatic, inflammatory, and immuneresponses. Methods/Principal Findings Next generation sequencing...