3 documents found, page 1 of 1
The treadmill exercise protects against dopaminergic neuron loss and brain oxid...
Costa, Roberta Oliveira da; Gadelha-Filho, Carlos Vinicius Jataí; Costa, Ayane Edwiges Moura da; Feitosa, Mariana Lima; Araújo, Dayane Pessoa deParkinson’s disease (PD), a progressive neurological pathology, presents motor and nonmotor impairments. The objectives were to support data on exercise benefits to PD. Male Wistar rats were distributed into sham-operated (SO) and 6-OHDA-lesioned, both groups without and with exercise. The animals were subjected to treadmill exercises (14 days), 24 h after the stereotaxic surgery and striatal 6-OHDA injection. ...
Antidepressant effect of aminophylline after ethanol exposure
Escudeiro, Sarah Souza; Soares, Paula Matias; Almeida, Anália Barbosa; Lobato, Rodrigo de Freitas Guimarães; Araújo, Dayane Pessoa deThis work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in behavioral models by ...
Behavioral and neurochemical effects of alpha-lipoic acid in the model of Parki...
Araújo, Dayane Pessoa de; Sousa, Caren Nádia Soares De; Araújo, Paulo Victor Pontes; Menezes, Carlos Eduardo de SouzaThis study aimed to investigate behavioral and neurochemical effects of -lipoic acid (100mg/kg or 200mg/kg) alone or associated with L-DOPA using an animal model of Parkinson’s disease induced by stereotaxic injection of 6-hydroxydopamine (6-OHDA) in rat striatum. Motor behavior was assessed by monitoring body rotations induced by apomorphine, open field test and cylinder test. Oxidative stress was accessed by ...