3 documents found, page 1 of 1
The monoterpene (-)-carvone: A novel agonist of TRPV1 channels
Araújo, Demetrius Antonio Machado de
Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of centr...
Quintans-Júnior, Lucindo José; Silva, Davi Alves da; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Guimarães, Adriana GibaraAIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated ...
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine:...
Quintans-Júnior, Lucindo José; Silva, Davi Antas; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Siqueira, Rosana de SouzaWe investigated the antinociceptive and nerve excitability effects of the N-salicyloyltryptamine (NST) NST-treated mice exhibited a significant decrease in the number of writhes when 100 and 200 mg/kg (i.p.) were administered (i.p.). This effect was not antagonized by naloxone (1.5 mg/kg, i.p.). NST inhibited the licking response of the injected paw when 100 and 200 mg/kg were administered (i.p.) to mice in the...