Encontrados 2 documentos, a visualizar página 1 de 1
MLL2/KMT2D and MLL3/KMT2C expression correlates with disease progression and re...
Rabello, Doralina do Amaral; Ferreira, Vivian D’Afonseca da Silva; Coelho, Maria Gabriela Berzoti; Burin, Sandra Mara; Magro, Cíntia LeticiaBackground Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the BCR–ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved the treatment efficiency and survival of CML patients by targeting BCR–ABL tyrosine kinase. The disease shows three distinct clinica...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Carvalho, Amandda É. Silva; Cabral, Wanessa F.In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...