11 documents found, page 1 of 2

A hybrid bi-objective optimization approach for joint determination of safety s...

In material requirements planning (MRP) systems, safety stock and safety time are two well-known inventory buffering strategies to protect against supply and demand uncertainties. While the role of safety stocks in coping with uncertainty is well studied, safety time has received only scarce attention in the supply chain management literature. Particularly, most previous operations research models have typicall...

Application of Proteogenomics to Urine Analysis towards the Identification of N...

To identify new protein targets for PCa detection, first, a shotgun discovery experiment was performed to characterize the urinary proteome of PCa patients. This revealed 18 differentially abundant urinary proteins in PCa patients. Second, selected targets were clinically tested by immunoblot, and the soluble E-cadherin fragment was detected for the first time in the urine of PCa patients. Third, the proteogeno...

Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnosti...

We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline med...

Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnosti...

We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline med...

Profiling persistent asthma phenotypes in adolescents: A longitudinal diagnosti...

We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13–17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline med...

Feasibility and acceptability of an asthma app to monitor medication adherence:...

Poor medication adherence is a major challenge in asthma, and objective assessment of inhaler adherence is needed. The InspirerMundi app aims to monitor adherence while providing a positive experience through gamification and social support. This study aimed to evaluate the feasibility and acceptability of the InspirerMundi app to monitor medication adherence in adolescents and adults with persistent asthma (tr...

Cancer cells’ metabolism dynamics in renal cell carcinoma patients’ outcome: in...

The cancer cells’ metabolism is altered due to deregulation of key proteins, including glucose transporter 1 (GLUT-1), whose mRNA levels are influenced by microRNAs (miRNAs). Renal cell carcinoma (RCC) is the most common and lethal neoplasia in the adult kidney, mostly due to the lack of accurate diagnosis and follow-up biomarkers. Being a metabolic associated cancer, this study aimed to understand the hsa-miR-...

Adult asthma scores—development and validation of multivariable scores to ident...

One of the questions in epidemiology is the identification of adult asthma in studies. To develop and validate multivariable scores for adult asthma identification in epidemiological studies and to explore cutoffs to rule in/rule out asthma, compared with asthma diagnosed by a physician after clinical examination and diagnostic tests, blinded to the self-administered questions. We analyzed data (n = 711 adults)...

A Indústria Química Portuguesa

Thermal inertia walls in portuguese traditional rock for passive solar heating ...

A situação de Portugal é conhecida como de extrema dependência das energias fósseis, com as fraquezas próprias de tal situação. Neste contexto e tendo em conta o peso crescente do consumo de energia doméstica no total nacional em especial para o aquecimento dos edifícios, torna-se premente começar a equacionar, seriamente, o aumento do uso doméstico da energia solar. Impõe-se que uma nova abordagem da questão d...