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McCune-Albright syndrome - A case report with transmission electron microscopy
Garcia Neto,Victor; Almeida Jr,Hiram Larangeira de; Lorea,Claúdia Fernandes; Jorge,Valéria Magalhães; Almeida,Antônia Larangeira deAbstract McCune - Albright syndrome is a genetic disease with cutaneous mosaicism caused by post-zygotic activating mutations in GNAS locus, it has a triad of fibrous bone dysplasia, café-au-lait macules and precocious puberty. We examined a 22-year-old female patient with café au lait spot in right side of the abdomen, with a chessboard - like distribution, extending to right thigh with geographical contours, ...
Ultrastructural aspects of the skin in lipoid proteinosis (Urbach-Wiethe disease),
Almeida Jr,Hiram Larangeira de; Rodeghiero,Raphael Goveia; Suzuki,Patrícia Naomi Ando; Ogawa,Marília MarufujiAbstract Lipoid proteinosis is a rare autosomal recessive disease, characterized by hyaline deposits of PAS-positive material in tissues due to mutations in the ECM1 gene. This study evaluated the ultrastructure of the skin of a 6-year-old child affected by this condition. The light microscopy identified PAS-positive hyaline deposits, which were more intense in the papillary dermis. Scanning electron microscopy...
Infantile generalized hypertrichosis caused by topical minoxidil
Rampon,Greice; Henkin,Caroline; Souza,Paulo Ricardo Martins de; Almeida Jr,Hiram Larangeira deAbstract Rare cases of hypertrichosis have been associated with topically applied minoxidil. We present the first reported case in the Brazilian literature of generalized hypertrichosis affecting a 5-year-old child, following use of minoxidil 5%, 20 drops a day, for hair loss. The laboratory investigation excluded hyperandrogenism and thyroid dysfunction. Topical minoxidil should be used with caution in children.
Pitted keratolysis
Almeida Jr,Hiram Larangeira de; Siqueira,Rodrigo Nunes; Meireles,Renan da Silva; Rampon,Greice; Castro,Luis Antonio Suita de; Silva,Ricardo Marques eAbstract Pitted keratolysis is a skin disorder that affects the stratum corneum of the plantar surface and is caused by Gram-positive bacteria. A 30-year-old male presented with small punched-out lesions on the plantar surface. A superficial shaving was carried out for scanning electron microscopy. Hypokeratosis was noted on the plantar skin and in the acrosyringium, where the normal elimination of corneocytes ...
Is adermatoglyphia an additional feature of Kindler Syndrome?
Almeida Jr,Hiram Larangeira de; Goetze,Fernanda Mendes; Fong,Kenneth; Lai-Cheong,Joey; McGrath,JohnAbstractA typical feature of Kindler Syndrome is skin fragility; this condition in currently classified as a form of epidermolysis bullosa. We describe a rarely reported feature of two cases, one sporadic and one familial; both patients noticed acquired adermatoglyphia. The loss of dermatoglyphics could be an additional feature of this syndrome.
Scanning electron microscopy of tinea nigra
Guarenti,Isabelle Maffei; Almeida Jr,Hiram Larangeira de; Leitão,Aline Hatzenberger; Rocha,Nara Moreira; Silva,Ricardo Marques eTinea nigra is a rare superficial mycosis caused by Hortaea werneckii. This infection presents as asymptomatic brown to black maculae mostly in palmo-plantar regions. We performed scanning electron microscopy of a superficial shaving of a tinea nigra lesion. The examination of the outer surface of the sample showed the epidermis with corneocytes and hyphae and elimination of fungal filaments. The inner surface ...
Comparative scanning electron microscopy of bullous diseases
Almeida Jr,Hiram Larangeira de; Rossi,Gabriela; Karam,Octavio Ruschel; Rocha,Nara Moreira; Silva,Ricardo Marques eThe purpose of this study is to compare scanning electron microscopy findings of the blister roof in three distinct bullous diseases: one intraepidermal acantholytic (pemphigus foliaceus); one due to hemidesmosomal dysfunction (bullous pemphigoid); and one secondary to anchoring fibril dysfunction - type VII collagen (dystrophic epidermolysis bullosa). In pemphigus foliaceus, acantholytic phenomena were readily...
Scanning electron microscopy of molluscum contagiosum*
Almeida Jr,Hiram Larangeira de; Abuchaim,Martha Oliveira; Schneide,Maiko Abel; Marques,Leandra; Castro,Luis Antônio Suíta deMolluscum contagiosum is a disease caused by a poxvirus. It is more prevalent in children up to 5 years of age. There is a second peak of incidence in young adults. In order to examine its ultrastructure, three lesions were curetted without disruption, cut transversely with a scalpel, and routinely processed for scanning electron microscopy (SEM). The oval structure of molluscum contagiosum could be easily iden...
Scanning electron microscopy of lichen sclerosus
Almeida Jr,Hiram Larangeira de; Bicca,Eduardo de Barros Coelho; Breunig,Juliano de Avelar; Rocha,Nara Moreira; Silva,Ricardo Marques eLichen sclerosus is an acquired inflammatory condition characterized by whitish fibrotic plaques, with a predilection for the genital skin. We performed scanning electron microscopy of the dermis from a lesion of lichen sclerosus. Normal collagen fibers could be easily found in deeper layers of the specimen, as well as the transition to pathologic area, which seems homogenized. With higher magnifications in thi...
Prevalence of sun exposure and its associated factors in southern Brazil: a pop...
Duquia,Rodrigo Pereira; Menezes,Ana Maria Baptista; Almeida Jr,Hiram Larangeira de; Reichert,Felipe Fossati; Santos,Iná da Silva dosBACKGROUND: Sunlight exposure is responsible for a large number of dermatological diseases.OBJECTIVE: We estimated the prevalence of sunlight exposure and its associated factors in adults from southern Brazil in a cross-sectional, population-based study.METHODS:We investigated a representative sample of individuals aged ≥ 20 years (n=3,136). Sunlight exposure and its associated factors were evaluated in two dis...