12 documents found, page 1 of 2

Screening for Autism Spectrum Disorders-Validation of the Portuguese Version of...

There are no assessment and screening tools for Autism Spectrum Disorders (ASD) validated for the Portuguese population. The Social Communication Questionnaire (SCQ) is an useful screening tool of ASD diagnosis. The main objectives of our study were to produce a Portuguese version of the SCQ (SCQ-PF), study its internal consistency, sensitivity and specificity in order to evaluate its validity as a screening in...

Immunoallergic Disorders in the Elderly

Although allergic diseases have become increasingly prevalent in the elderly, there are few data on this population. Through a retrospective analysis of the electronic medical records of patients aged 65 years and above followed in our Immunoallergology Unit, we aimed to characterize the immunoallergic diseases of the elderly. The most common disorders were respiratory diseases (n = 185; 50%), mucocutaneous dis...

Hoxb7 overexpression leads triple-negative breast cancer cells to a less aggres...

HOX genes appear to play a role in breast cancer progression in a molecular subtype-dependent way. The altered expression of HOXB7, for example, was reported to promote breast cancer progression in specific subtypes. Here we induced HOXB7 overexpression in MDA-MB-231 cells, a cellular model of the Triple-Negative breast cancer molecular subtype, and evaluated the phenotypic changes in cell viability, morphogene...

Dataset of HOXB7, HOXB8 and HOXB9 expression profiles in cell lines representat...

Alterations in HOXB genes expression in breast cancer have been described and related to therapy response and disease progression. However, due to breast cancer complexity and heterogeneity, added to the use of different technical approaches, the observed expression profiles are sometimes contradictory. Here, we provided the analyses of HOXB7, HOXB8 and HOXB9 expression profiles in cell lines extensively used i...

Glycosaminoglycan-inspired biomaterials for the development of bioactive hydrog...

Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to ...

Molecular ontogeny of the stomach in the catshark Scyliorhinus canicula

The origin of extracellular digestion in metazoans was accompanied by structural and physiological alterations of the gut. These adaptations culminated in the differentiation of a novel digestive structure in jawed vertebrates, the stomach. Specific endoderm/mesenchyme signalling is required for stomach differentiation, involving the growth and transcription factors: 1) Shh and Bmp4, required for stomach outgro...

Strategies to obtain designer polymers based on cyanobacterial extracellular po...

Biopolymers derived from polysaccharides are a sustainable and environmentally friendly alternative to the synthetic counterparts available in the market. Due to their distinctive properties, the cyanobacterial extracellular polymeric substances (EPS), mainly composed of heteropolysaccharides, emerge as a valid alternative to address several biotechnological and biomedical challenges. Nevertheless, biotechnolog...

Mucosite Multifocal Recorrente - Nova Cara de uma Velha Doença?

Introdução:A Síndrome de Stevens-Johnson (SSJ), caracterizada por necrose mucocutânea imunomediada, é uma entidade rara em pediatria, com risco de vida e sequelas cicatriciais. O Mycoplasmapneumoniae e alguns fármacos integram os despoletantes mais comuns, sendo 33% dos casos idiopáticos. A recorrência, rara em adultos, atinge 18% dos casos pediátricos. Resumo de Caso:Criança de 8 anos, sexo masculino, com ante...

Síndrome febril indeterminada: uma causa rara

Dyschromatopsia in Multiple Sclerosis Patients: A Marker of Subclinical Involve...

BACKGROUND: In multiple sclerosis (MS), even in the absence of a clinical episode of optic neuritis (ON), the optic nerve and retinal nerve fiber layer (RNFL) may be damaged leading to dyschromatopsia. Subclinical dyschromatopsia has been described in MS associated with lower motor and cognitive performances. OBJECTIVES: To set the prevalence of dyschromatopsia in eyes of MS patients without a history of ON, to...