4 documents found, page 1 of 1
Evolutionary genetics of Mycobacterium tuberculosis and HIV-1: “The Tortoise an...
Santos-Pereira, Ana; Magalhães, Carlos André Rodrigues; Araújo, Pedro M. M.; Osório, Nuno S.The already enormous burden caused by Mycobacterium tuberculosis and Human Immunodeficiency Virus type 1 (HIV-1) alone is aggravated by co-infection. Despite obvious differences in the rate of evolution comparing these two human pathogens, genetic diversity plays an important role in the success of both. The extreme evolutionary dynamics of HIV-1 is in the basis of a robust capacity to evade immune responses, t...
Nationwide study of drug resistance mutations in HIV-1 infected individuals und...
Santos-Pereira, Ana; Triunfante, Vera; Araújo, Pedro M. M.; Martins, Joana; Soares, Helena; Poveda, Eva; Souto, Bernardino; Osório, Nuno S.The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). Since Brazil presents the largest number of people living with HIV (PLWH) in South America we aimed at understanding the dynamics of DRM in this country. We analyzed a total of 20,226 HIV-1 sequences collected from PLWH undergoing ART between 2008–2017. Results show a mild decline of DRM over the yea...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M. M.; Carvalho, Alexandre; Pingarilho, Marta; Abecasis, Ana B.; Osório, Nuno S.; Rodrigues, Fernando; Ramos, Helena; Neves, IsabelHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M. M.; Carvalho, Alexandre; Pingarilho, Marta; BEST-HOPE study group; Abecasis, Ana B.; Osório, Nuno S.HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...