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Anticonvulsant property of N-salicyloyltryptamine: evidence of enhance of centr...

Quintans-Júnior, Lucindo José; Silva, Davi Alves da; Quintans, Jullyana de Souza Siqueira; Araújo, Adriano Antunes de Souza; Guimarães, Adriana Gibara

AIM: In the present study we verified the anticonvulsant properties of the new tryptamine analogue, N-salicyloyltryptamine (NST), in rodents. METHODS AND RESULTS: In the evaluation of the anticonvulsant activity, NST protected the animals from the incidence of seizures induced by pentylenetetrazole (PTZ) and picrotoxin (PIC), in doses of 100 and 200 mg/kg. NST (100 and 200 mg/kg, i.p.) significantly eliminated ...

Date: 2013   |   Origin: Oasisbr
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