2 documents found, page 1 of 1
Double-blind clinical trial of arginine supplementation in the treatment of adu...
Eleutério, Renata Mirian Nunes; Nascimento, Francisco O.; Araújo, Tamara G.; Castro, Marilena F.; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...
Preliminary evaluation of novel triglyceride-based nanocomposites for biomedica...
Almeida, Raimundo R. de; Gallo, Juan; Silva, Aiêrta C. C. da; Silva, Ana K. O. da; Pessoa, Otilia D. L.; Araújo, Tamara G.This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporation method. The developed MSLNs were subjected to an e...