4 documents found, page 1 of 1
Hepatitis C: sexual or intrafamilial transmission? Epidemiological and phylogen...
Cavalheiro,Norma de Paula; De La Rosa,Abel; Elagin,Slava; Tengan,Fátima Mitiko; Araújo,Evaldo Stanislau Affonso de; Barone,Antonio AlciThe role of sexual or intrafamilial transmission of hepatitis C is controversial. A phylogenetic analysis was performed on the non-structural region 5B of the hepatitis C virus (NS5B-HCV). High percentages of homology (mean of 98.3%) were shown between the couples. Twenty (83.3%) of the 24 men but only two of the women (8.3%) reported having had sexually transmitted diseases during their lives. The risk factors...
Hepatitis C treatment: shorter and better?
Araújo,Evaldo Stanislau Affonso de; Courtouké,Cláudia; Barone,Antonio AlciHerein, we present a synthesis of two publications that evaluate an abbreviated therapeutic approach to treating chronic hepatitis C virus (HCV) infection. Based on those publications, we discuss the use of the early virologic response (EVR) as a tool for the optimized management of patients under treatment, as well as reviewing concepts of HCV viral kinetics. The fourth-week EVR, characterized by HCV RNA dropp...
Detection of HCV by PCR in serum and PBMC of patients with hepatitis C after tr...
Cavalheiro,Norma de Paula; Filgueiras,Thelma Cristina; Melo,Carlos Eduardo; Morimitsu,Suzana Rie; Araújo,Evaldo Stanislau Affonso deAlthough hepatitis C is mainly hepatotropic, some studies suggest that hepatitis C virus (HCV) infects peripheral blood mononuclear cells (PBMC), using them as a reservoir, which might contribute to the development of resistance to treatment. Fifty-four hepatitis-C patients, who had been submitted to treatment, were selected. Blood samples were collected on the same day for the detection of HCV RNA in serum and...
Consensus of the Brazilian Society of Infectious Diseases on the management and...
Araújo,Evaldo Stanislau Affonso de; Mendonça,João Silva; Barone,Antonio Alci; Gonçales Junior,Fernando Lopes; Ferreira,Marcelo Simão; Focaccia,Roberto