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Severely impaired terminal erythroid differentiation as an independent prognost...

Ali, Abdullah Mahmood; Huang, Yumin; Pinheiro, Ronald Feitosa; Xue, Fumin; Hu, Jingping; Iverson, Nicholas; Hoehn, Daniela; Coutinho, Diego

Anemia is the defining feature in most patients with myelodysplastic syndromes (MDS), yet defects in erythropoiesis have not been well characterized. We examined freshly obtained bone marrow (BM) samples for stage-specific abnormalities during terminal erythroid differentiation (TED) from 221 samples (MDS, n = 205 from 113 unique patients; normal, n = 16) by measuring the surface expression of glycophorin A, ba...

Date: 2018   |   Origin: Oasisbr
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