3 documents found, page 1 of 1
Lactate-coated polyurea-siRNA dendriplex
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; JS, Ramalho; Ceña, Valentin; D. B. Bonifácio, Vasco; G Goncalves, Luis; Serpa, JacintaFunding Information: This work benefited from access to CERMAX, ITQB-NOVA, Oeiras, Portugal with equipment funded by FCT, project AAC 01/SAICT/2016. Funding Information: The institutions are funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia/Minist\u00E9rio da Ci\u00EAncia, Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020...
Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolis...
Martins, Filipa; Arada, Renata; Barros, Hélio; Matos, Paulo; Ramalho, José; Ceña, Valentín; Bonifácio, Vasco D.B.; Gonçalves, Luís G.; Serpa, JacintaGlioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE) surface function...
Metabolic implosion : engineered nanothrapeutics for glioblastoma shutdown (GBMBS)
Arada, RenataGlioblastoma (GBM) represents one of the most aggressive and treatment-resistant forms of brain cancer, necessitating innovative therapeutic strategies. This study explores the potential of a novel dendrimer-based delivery system PUREG4-LA12 and its siRNA complex (the dendriplex PUREG4-LA12:siRNA – GBMBs), to take advantage of glucose/lactate and glutamine reliance and disrupt GBM metabolic pathways. PUREG4-LA1...