6 documents found, page 1 of 1
Caspases and p53 Modulate FOXO3A/Id1 Signaling During Mouse Neural Stem Cell Di...
Aranha, Marcia M.; Sola, Susana; Low, Walter C.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Neural stem cells (NSCs) differentiate into neurons and glia, and a large percentage undergoes apoptosis. The engagement and activity of apoptotic pathways may favor either cell death or differentiation. In addition, Akt represses differentiation by up-regulating the inhibitor of differentiation 1 (Id 1), through phosphorylation of its repressor FOXO3A. The aim of this study was to investigate the potential cro...
Bile acid levels are increased in the liver of patients with steatohepatitis
Aranha, Marcia M.; Cortez-Pinto, Helena; Costa, Adilia; da Silva, Isabel B. Moreira; Camilo, Maria E.; de Moura, Miguel CarneiroBackground/aims The pathogenesis of steatohepatitis remains largely unknown; however, bile acids may play a role as potential mediators of liver damage. The aim of this study was to characterize bile acid profiles in liver tissue of patients with steatohe
Game and players
Sola, Susana; Aranha, Marcia M.; Steer, Clifford J.; Rodrigues, Cecilia M. P.Apoptosis represents a universal and exquisitely efficient cellular suicide pathway essential for a variety of normal biological processes ranging from embryonic development to ageing. In fact, tissue homeostasis is dependent on the perfect balance betwee
Dinitro-o-cresol induces apoptosis-like cell death but not alternative oxidase ...
Aranha, Marcia M.; Matosa, Ana R.; Mendes, Ana Teresa; Pinto, Vera Vaz; Rodrigues, Cecilia M. P.; Arrabaca, Joao D.In plants, programmed cell death is thought to be activated during differentiation and in response to biotic and abiotic stresses. Although its mechanisms are far less clear, several morphological and biochemical features have been described in different experimental systems, including DNA laddering and cytosolic protease activation. Moreover, plant mitochondria have an alternative terminal oxidase (AOX), which...
Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis...
Borralho, Pedro M.; da Silva, Isabel B. Moreira; Aranha, Marcia M.; Albuquerque, Cristina; Leitao, Carlos Nobre; Steer, Clifford J.Drug resistance to 5-fluorouracil (5-FU) is still a major limitation to its clinical use. In addition, the clinical value of p53 as a predictive marker for 5-FU-based chemotherapy remains a matter of debate. Here, we used HCTI 16 human colorectal cancer c
Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid...
Sola, Susana; Amaral, Joana D.; Borralho, Pedro M.; Ramalho, Rita M.; Castro, Rui E.; Aranha, Marcia M.; Steer, Cifford J.; Rodrigues, Cecilia M. P.Tauroursodeoxycholic acid ( TUDCA) prevents amyloid beta-peptide (A beta)-induced neuronal apoptosis, by modulating both classical mitochondrial pathways and specific upstream targets. In addition, activation of nuclear steroid receptors (NSRs), such as t