Acute porphyrias are a group of rare metabolic diseases, arise from defects in the heme biosynthesis pathway. These conditions are clinically characterized by acute neurovisceral attacks, chronic symptoms, and long-term complications. Given the non-specific presentation and the typically low index of clinical suspicion, diagnostic delays are recurrent and result in significant preventable morbimortality. To add...
Cooperative Learning is an active, student-centred methodology that promotes meaningful, inclusive and dynamic learning based on peer cooperation. This article analyses the benefits of this approach in the process of inclusion and in strengthening students' interpersonal relationships. The study design was based on qualitative and interpretative action research, organised into four stages: observation, planning...
Cooperative Learning is an active methodology, characterized by the use of small heterogeneous groups, which places students at the center of the teaching-learning-evaluation trilogy, promoting the development of both academic and social skills. This article aims to articulate the theoretical and practical dimensions of this methodology, based on the description, analysis and reflection of the implementation of...
This article aims to analyze the impact of the implementation of the Coopera Escola+ Project (21I23 and 23I24), developed with teachers and students from different regions and educational levels, based on the active methodology of Cooperative Learning (CL). Integrated into the national strategy Recovering by Including through Cooperative Learning, under the axis “Teaching and Learning”, the project sought to im...
Fatty acid (FA) oxidation disorders (FAOD) are characterized by accumulation of specific acylcarnitines (CAR)and FA and can lead to potentially severe complications. In this study, dried blood spots (DBS) combined with LC-MS lipidomics analysis were used to assess lipidome plasticity in medium-chain acyl-CoA dehydrogenase deficiency (MCADD), long-chain hydroxyacyl-CoA dehydrogenase deficiency (LCHADD), and very...
Fatty acid (FA) oxidation disorders (FAOD) are characterized by accumulation of specific acylcarnitines (CAR) and FA and can lead to potentially severe complications. In this study, dried blood spots (DBS) combined with LC-MS lipidomics analysis were used to assess lipidome plasticity in medium-chain acyl-CoA dehydrogenase deficiency (MCADD), long-chain hydroxyacyl-CoA dehydrogenase deficiency (LCHADD), and ver...
O presente livro assenta, em grande medida, na versão escrita do tema que foi apresentado pelos palestrantes na conferência internacional A proteção da pessoa idosa, realizada no dia 17 de novembro de 2023, na Escola de Direito da Universidade do Minho, organizada pelo JusGov (Escola de Direito da Universidade do Minho). Esta conferência insere-se no primeiro momento do projeto A proteção da pessoa vulnerável –...
Introduction: Erythema nodosum is a rare disease whose pathophysiology is based on a type 4 delayed hypersensitivity response and its most common form of presentation is in the form of bilateral and symmetrical nodules and cutaneous plaques, predominantly affecting the pre-tibial region. Although the idiopathic etiology is still quite frequent, close to half of the cases are of secondary etiology, with oral con...