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Induction of G2/M arrest, caspase activation and apoptosis by a-santonin deriva...
Ferreira, José Roberto Oliveira; Cavalcanti, Bruno Coêlho; Costa, Patricia Marçal da; Arantes, Francisco Frederico Perlinson deSesquiterpene lactones (SLs) are natural products with a variety of biological activities. Previously, we demonstrated the cytotoxic effects of three new a-santonin derivatives on different tumor cell lines with low toxic effects upon peripheral human leukocytes. Here, we evaluated the mechanism of action triggered by these derivatives. HL-60 cell cycle determined after 24 h treatment revealed a significant inh...
Data: 2014
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Origem: Oasisbr