3 documents found, page 1 of 1
Trypanosoma cruzi : treatment with the iron chelator desferrioxamine reduces pa...
Arantes, Jerusa Marilda; Pedrosa, Maria Lúcia; Martins, Helen Rodrigues; Veloso, Vanja Maria; Lana, Marta de; Bahia, Maria TerezinhaThe effects of prolonged treatment with iron chelator (desferrioxamine) on the development of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated mice presented lower levels of parasitemia and reduced mortality rate compared with infected/non-treated animals. The five out of twenty infected/treated mice that survived the acute phase of infection showed negative hemoculture an...
Trypanosoma cruzi : desferrioxamine decreases mortality and parasitemia in infe...
Arantes, Jerusa Marilda; Francisco, Amanda Fortes; Vieira, Paula Melo de Abreu; Silva, Maísa; Araújo, Márcio Sobreira SilvaDesferrioxamine (DFO) is a potent iron chelator that is also known to modulate inflammation and act as an efficient antioxidant under normal conditions and under oxidative stress. Many in vitro and in vivo studies have shown the efficacy of DFO in the treatment of viral, bacterial and protozoan infections. DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of thera...
Trypanosoma cruzi : effect of benznidazole therapy combined with the iron chela...
Francisco, Amanda Fortes; Vieira, Paula Melo de Abreu; Arantes, Jerusa Marilda; Pedrosa, Maria Lúcia; Martins, Helen Rodrigues; Silva, MaísaIron chelators have been employed in various studies aimed at evaluating the relationship between the iron status of the host and the development of infection. In the present study, the effects of benznidazole (BZ) therapy in combination with the iron chelator desferrioxamine (DFO) on the development of infection in mice inoculated with Trypanosoma cruzi Y strain have been investigated. Infected mice treated wi...