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Variation in neuronal differentiation of a newly isolated mouse embryonic stem ...
Tavares, Rubens Lene Carvalho; Cortes, Paloma Alvarenga; Azevedo, Camila Issa de; Cangussú, Silvia Dantas; Camargos, Aroldo FernandoNeural precursor differentiation from mouse ES (embryonic stem) cells have been demonstrated using EB (embryoid body), co-culture on stromal feeder layers, and in the absence of external inducing signals. Most of available mouse ES cell original research articles have worked with only six different cell lines. Our goals were to isolate one new mouse ES lineage, and perform a detailed immunocytochemistry study d...
Enteric neuronal damage, intramuscular denervation and smooth muscle phenotype ...
Campos, Camila França; Cangussú, Silvia Dantas; Duz, Ana Luiza Cassin; Cartelle, Christiane Teixeira; Noviello, Maria de Lourdes; Veloso, Vanja MariaWe developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in ord...
Mast cell concentration and skin wound contraction in rats treated with Brazili...
Estevão, Lígia Reis Moura; Medeiros, Juliana Pinto De; Simões, Ricardo Santos; Arantes, Rosa Maria Esteves; Rachid, Milene AlvarengaMade available in DSpace on 2015-08-21T17:54:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-01. Added 1 bitstream(s) on 2015-08-24T14:42:07Z : No. of bitstreams: 1 S0102-86502015000400289.pdf: 668960 bytes, checksum: 9c4cbd8871fd8362e8521af011cdceed (MD5); PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in r...
Interferon-y-induced nitric oxide causes intrinsic intestinal denervation in Tr...
Arantes, Rosa Maria Esteves; Marche, Homero H. F.; Bahia, Maria Terezinha; Cunha, Fernando de Queiroz; Rossi, Marcos Antonio; Silva, João Santana daIn this study, the role of nitric oxide (NO) in neuronal destruction during acute-phase Trypanosoma cruzi infection was evaluated in male C57BL/6 (WT, wildtype) mice and knockout mice [inducible nitric oxide synthase (iNOS)_/_ and interferon (IFN)_/_]. Selected animals were infected by intraperitoneal injection of 100 trypomastigote forms of the Y strain of T. cruzi. Others were injected intraperitoneally with ...
Histopathology of Leishmania major infection : revisiting L. major histopatholo...
Cangussú, Silvia Dantas; Souza, Carolina Carvalho de; Campos, Camila França; Vieira, Leda Quercia; Afonso, Luís Carlos CroccoWe describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellula...
Interferon-γ induced nitric oxide mediates in vitro neuronal damage by Trypanos...
Leite, Camila Megale Almeida; Galvão, Lúcia Maria da Cunha; Afonso, Luís Carlos Crocco; Cunha, Fernando de Queiroz; Arantes, Rosa Maria EstevesNeuronal lesions and peripheral denervation in Chagas' disease are related to local inflammation; however, the pathogenic mechanisms of neuronal lesions in the heart and megavisceras are still unclear. We investigated the involvement of nitric oxide (NO) on neuronal lesion in co-cultures of neurons and macrophages. Trypanosoma cruzi-infected and interferon-γ (IFN-γ)-activated co-cultures of neurons and wildtype...
The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania...
Cangussú, Silvia Dantas; Souza, Carolina Carvalho de; Castro, Maria Salete de Abreu; Vieira, Leda Quercia; Cunha, Fernando de QueirozSeveral reports have shown that cutaneous leishmaniasis lesions are painless, suggesting that Leishmania infection interferes with pain perception. Comparisons of inflammation-induced hyperalgesia between BALB/c and C57BL/6 mice have been little explored in the literature, and comparative data regarding nociception in leishmaniasis are non-existent. In susceptible BALB/c mice and resistant C57BL/6 mice that wer...
Virulence in murine model shows the existence of two distinct populations of Br...
Ferreira, Jaqueline Maria Siqueira; Drumond, Betânia Paiva; Guedes, Maria Isabel Maldonado Coelho; Xavier, Marcelo Antônio PascoalBrazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological ch...