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In vivo and in vitro effects of RAD001 on bladder cancer

Vasconcelos-Nóbrega, Carmen; Pinto-Leite, Rosário; Arantes-Rodrigues, Regina; Ferreira, Rita; Brochado, Paulo; Cardoso, Maria L.; Palmeira, Carlos

Objective: To evaluate the influence of Everolimus (RAD001) on chemically induced urothelial lesions in mice and its influence on in vitro human bladder cancer cell lines. Methods: ICR male mice were given N-butyl-N-(4-hydroxybutyl) nitrosamine in drinking water for a period of 12 weeks. Subsequently, RAD001 was administered via oral gavage, for 6 weeks. At the end of the experiment, all the animals were sacrif...

Date: 2011   |   Origin: Repositório Científico do Instituto Politécnico de Lisboa
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