6 documents found, page 1 of 1
Assessment of MLL methyltransferase gene expression in larynx carcinoma
Figueiredo, David Livingstone Alves; Ramos, Doralina do Amaral Rabello; Zanette, Dalila Luciola; Saggioro, Fabiano Pinto; Mamede, Rui Celso MartinsLarynx cancer is the second most common type of cancer among all head and neck cancers. Deregulation of epigenetic effectors, including altered expression of histone methyltransferases from the MLL (mixed lineage leukemia) family, have been reported in many cancer types, yet little is known concerning their involvement in larynx cancer. Our objective was to determine the expression profile of MLL genes in laryn...
The inflammatory status of soluble microenvironment influences the capacity of ...
Bogéa, Gabriela Muller Reche; Carvalho, Amandda Évelin Silva; Braga, Luma Dayane de Carvalho Filiú; Neves, Francisco de Assis RochaThe development of immunotherapeutic approaches for the treatment of melanoma requires a better understanding of immunoescape mechanisms of tumor cells and how they interact with other tumor-resident cell types. Here, we evaluated how the conditioned media of resting (rCM) and immune-activated PBMCs (iCM) influence the ability of a metastatic melanoma cell line (MeWo) to control T-cells function. MeWo cells wer...
Commentary : mesenchymal stem cells : a new piece in the puzzle of COVID-19 tre...
Carvalho, Juliana Lott; Melgaço Garcez, Emãnuella; Carvalho, Amandda Évelin Silva; Araujo, Felipe Saldanha deA Commentary on Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 Treatment By Saldanha-Araujo F, Melgaço Garcez E, Silva-Carvalho AE and Carvalho JL (2020). Front. Immunol. 11:1563. doi: 10.3389/fimmu.2020.01563.
Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
Araujo, Felipe Saldanha de; Melgaço Garcez, Emãnuella; Carvalho, Amandda Évelin Silva; Carvalho, Juliana LottCOVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underl...
GVHD-derived plasma as a priming strategy of mesenchymal stem cells
Carvalho, Amandda Évelin Silva; Rodrigues, Leane Perim; Schiavinato, Josiane Lilian; Alborghetti, Marcos Rodrigo; Bettarello, GustavoBackground: Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of MSCs constitute an active area of investigation. Here, we proposed an innovative priming strategy based on the plasma obtained from GVHD patients and tested whether this approach could enhance ...
LL-37 boosts immunosuppressive function of placenta-derived mesenchymal stromal...
Bravo, Martha Oliveira; Sangiorgi, Bruno Braga; Schiavinato, Josiane Lilian dos Santos; Carvalho, Juliana Lott; Covas, Dimas TadeuBackground: Although promising for graft-versus-host disease (GvHD) treatment, MSC therapy still faces important challenges. For instance, increasing MSC migratory capacity as well as potentializing immune response suppression are of interest. For GvHD management, preventing opportunistic infections is also a valuable strategy, since immunocompromised patients are easy targets for infections. LL-37 is a host de...