6 documents found, page 1 of 1
Clinical performance of an infliximab rapid quantification assay
Magro, Fernando; Afonso, Joana; Lopes, Susana; Coelho, Rosa; Gonçalves, Raquel; Caldeira, Paulo; Lago, Paula; Sousa, Helena Tavares; Ramos, JaimeBackground: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. Methods: This manuscript describes a prospective cohort study involving 110 ulcerative colitis (UC) patients on the maintenance phase of IFX. IFX trough levels were q...
Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable...
Magro, Fernando; Afonso, Joana; Lopes, Susana; Coelho, Rosa; Gonçalves, Raquel; Caldeira, Paulo; Lago, Paula; Sousa, Helena Tavares; Ramos, JaimeAlthough infliximab (IFX) is an efficient therapy for ulcerative colitis (UC) patients, a considerably high rate of therapeutic failures still occurs. This study aimed at a better understanding of IFX pharmacokinetics and pharmacodynamics among clinically-asymptomatic UC patients. This was a multicentric and prospective study involving 65 UC patients in the maintenance phase of IFX therapy. There were no signif...
Interobserver agreement of contrast-enhanced harmonic endoscopic ultrasonograph...
Soares, João-Bruno; Iglesias-Garcia, Julio; Gonçalves, Bruno; Lindkvist, Björn; Lariño-Noia, Jose; Bastos, Pedro; Caetano, Ana Célia; Ferreira, Aníbal[Excerpt] Previous reports assessing the reproducibility of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) in the evaluation of solid pancreatic lesions (SPLs) involved mainly experienced endosonographers. We aimed to assess the interobserver agreement (IOA) of CH-EUS in the evaluation of SPLs by endoscopists with different levels of experience in EUS and CH-EUS. [...]
Gastric mixed adenoneuroendocrine carcinoma
Fernandes, Dália; Soares, João-Bruno; Rolanda, Carla[Excerpt] Gastrointestinal mixed adenoneuroendocrine carcinomas (MANECs) are rare tumors and, as the name implies, are characterized by the presence of both components, exocrine and neuroendocrine, each one representing at least 30% of the lesion.1 It is unclear if they originate from proliferation of different cell lineages or from stem cells capable of differentiating along multiple cell lineages. They may pr...
Interobserver agreement of EUS elastography in the evaluation of solid pancreat...
Soares, João-Bruno; Iglesias-Garcia, Julio; Goncalves, Bruno; Lindkvist, Björn; Lariño-Noia, Jose; Bastos, Pedro; Caetano, Ana Cá Lia; Ferreira, AnIbalPrevious reports assessing the reproducibility of endoscopic ultrasound elastography (EUS-E) in evaluation of solid pancreatic lesions (SPL) involved only experienced endosonographers. We aimed to assess the interobserver agreement (IOA) of EUS-E in the evaluation of SPL by endoscopists with different levels of experience in EUS and EUS-E.
Interobserver agreement of EUS elastography in the evaluation of solid pancreat...
Soares, João-Bruno; Iglesias-Garcia, Julio; Goncalves, Bruno; Lindkvist, Björn; Lariño-Noia, Jose; Bastos, Pedro; Caetano, Ana Célia; Ferreira, AnibalPrevious reports assessing the reproducibility of endoscopic ultrasound elastography (EUS-E) in evaluation of solid pancreatic lesions (SPL) involved only experienced endosonographers. We aimed to assess the interobserver agreement (IOA) of EUS-E in the evaluation of SPL by endoscopists with different levels of experience in EUS and EUS-E.