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PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH...
Biasetto,Carolina R.; Somensi,Andressa; Abdalla,Viviane de C. P.; Abreu,Lucas M. de; Gualtieri,Sonia C. J.; Pfenning,Ludwig H.; Bolzani,Vanderlan da S.The upscaling of Xylaria cubensis, an endophyte of Eugenia brasiliensis (Myrtaceae), in PDB medium led to the isolation of known compounds including cytochalasin D (7) and cytochalasin C (8), which exhibited relatively higher phytotoxic activity in all the concentrations tested compared to the commercial herbicide GOAL®. Besides the aforementioned metabolites, one diketopiperazine (DKP) and two isocoumarins wer...
Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola s...
Borges,Maiara S.; Biasetto,Carolina R.; Chapla,Vanessa M.; Ebrahimi,Samad N.; Costa,Mayra F.; Bolzani,Vanderlan S.; Araujo,Angela R.A new compound named methyl (6S,7S,2E,4E)-6,7-dihydroxy-4,6-dimethyl octanoate was isolated from Saccharicola sp. using high performance liquid chromatography-solid phase extraction-transfer tube (HPLC-SPE-TT), together with four known compounds, fusaric acid, trans-4-hydroxymellein, thymidine and adenosine. Saccharicola sp. was isolated from the stems of Eugenia jambolana Lam. (Myrtaceae) as endophytic fungus....
Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colleto...
Chapla,Vanessa M.; Zeraik,Maria L.; Cafeu,Mariana C.; Silva,Geraldo H.; Cavalheiro,Alberto J.; Bolzani,Vanderlan S.; Young,Maria C. M.One new natural product, 1-phenylethyl-O-a-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia s...
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versic...
Gubiani,Juliana R.; Teles,Helder L.; Silva,Geraldo H.; Young,Maria Cláudia M.; Pereira,José O.; Bolzani,Vanderlan S.; Araujo,Angela R.Six known compounds, three peptide derivatives: cyclo-(tryptophyl-phenylalanyl) (2), diketopiperazine dimer WIN 64821 (3) and 3-hydroxy-15H-tryptophenaline (4), one adenine derivative: 2-hydroxy-6-N-isopentenyl-adenine (5), one phtalide derivative: 4-methoxyphtalide (1) and one benzoic acid derivative: 3-hydroxy-4-(1-hydroxy-1,5-dimethyl-hexyl) benzoic acid (6), were isolated from the ethyl acetate extract of t...
Antimicrobial Screening of Endophytic Fungi Isolated from the Aerial Parts of P...
Hilário,Felipe; Chapla,Vanessa M.; Araujo,Angela R.; Sano,Paulo T.; Bauab,Taís M.; Santos,Lourdes C. dosThe screening for antimicrobial activity of twenty five endophytic fungi isolated from the aerial parts of Paepalanthus chiquitensis (Eriocaulaceae) was assayed against the bacteria Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli and Salmonella setubal, and the yeast fluconazole-resistant Candida albicans. The ethyl acetate extract produced by Fusarium fujikuroi was the most bioactive and th...
Compounds of Anthostomella brabeji, an Endophytic Fungus Isolated from Paepalan...
Amorim,Marcelo R. de; Somensi,Andressa; Araujo,Angela R.; Bonifácio,Bruna V.; Bauab,Tais M.; Santos,Lourdes C. dosIn this study, fifteen endophytic fungi were isolated from Paepalanthus planifolius (Eriocaulaceae). From the capitula, seven endophytes were screened and evaluated for their metabolomic profile and radical scavenging activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay). Chemical investigation of ethyl acetate extract of the endophytic fungus Anthostomella brabeji resulted in the isolation of one new compound,...
ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS U...
Gubiani,Juliana R.; Habeck,Thomas R.; Chapla,Vanessa M.; Silva,Geraldo H.; Bolzani,Vanderlan S.; Araujo,Angela R.Seven phenolic derivatives including p-hydroxyphenyllactic acid (1), p-hydroxybenzoic acid (2), p-hydroxybenzaldehyde (3), phenyllactic acid (4), n-butyl-3,4-dihydroxybenzoate (5), n-hexyl-3,4-dihydroxybenzoate (6) and n-octyl-3,4-dihydroxybenzoate (7) were produced using Camarops sp. via the one strain-many compounds (OSMAC) approach. Their structures were determined using 2D NMR and ESI-MS spectra and were co...
Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
Prince,Karina Andrade de; Sordi,Renata; Pavan,Fernando Rogério; Santos,Adolfo Carlos Barreto; Araujo,Angela R.; Leite,Sergio R.A.; Leite,Clarice Q. F.Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium...
Sesquiterpenos produzidos pelo fungo endofítico Phomopsis cassiae com atividade...
Zanardi,Lisinéia M.; Bolzani,Vanderlan da S.; Cavalheiro,Alberto J.; Silva,Dulce H. Siqueira; Trevisan,Henrique C.; Araujo,Angela R.; Silva,Geraldo H.SESQUITERPENES PRODUCED BY ENDOPHYTIC FUNGUS Phomopsis cassiae WITH ANTIFUNGAL AND ACETYLCHOLINESTERASE INHIBITION ACTIVITIES. Two new diastereoisomeric cadinanes sesquiterpenes 3,9-dihydroxycalamenene (1-2), along with the known 3-hydroxycalamen-8-one (3) and aristelegone-A (4), were isolated from ethyl acetate extract of Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures, includin...
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum ...
Silva,Geraldo H.; Oliveira,Camila M. de; Teles,Helder L.; Bolzani,Vanderlan da S.; Araujo,Angela R.; Pfenning,Ludwig H.; Young,Maria Claudia M.A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines ...