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Coma in adult cerebral venous thrombosis: the BEAST study

Ranjan, Redoy; Ken‐Dror, Gie; Martinelli, Ida; Grandone, Elvira; Hiltunen, Sini; Lindgren, Erik; Margaglione, Maurizio; Duchez, Veronique Le Cam

Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positive...


Decompressive surgery in cerebral venous sinus thrombosis due to vaccine‐induce...

Krzywicka, Katarzyna; de Sousa, Diana Aguiar; Cordonnier, Charlotte; Bode, Felix J.; Field, Thalia S.; Michalski, Dominik; Pelz, Johann; Skjelland, Mona

Background and purpose: Cerebral venous sinus thrombosis due to vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is an adverse drug reaction occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. CVST-VITT patients often present with large intracerebral haemorrhages and a high proportion undergoes decompressive surgery. Clinical characteristics, therapeutic manag...


Endovascular treatment of cerebral sinus thrombosis due to vaccine-induced immu...

Weller, Johannes; Krzywicka, Katarzyna; van de Munckhof, Anita; Dorn, Franziska; Althaus, Katharina; Bode, Felix J.; Bandettini di Poggio, Monica

Introduction: There is little data on the role of endovascular treatment (EVT) of cerebral venous sinus thrombosis (CVST) due to vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we describe clinical characteristics and outcomes of CVST-VITT patients who were treated with EVT. Patients and methods: We report data from an international registry of patients who developed CVST within 28 days of SARS...


Acute symptomatic seizures in cerebral venous thrombosis

Lindgren, Erik; Silvis, Suzanne M.; Hiltunen, Sini; Heldner, Mirjam R.; Serrano, Fabiola; de Scisco, Michele; Zelano, Johan; Zuurbier, Susanna M.

Objective: To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium. Methods: We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdia...


The benefit of EXtending oral antiCOAgulation treatment EXCOA after acute cereb...

Miranda, Bruno; Aaron, Sanjith; Arauz, Antonio; Barinagarrementeria, Fernando; Borhani-Haghighi, Afshin; Carvalho, Marta; Conforto, Adriana B.

Rationale: After a cerebral vein thrombosis, there is an increased risk of further venous thromboembolic events. The optimal duration of anticoagulation after cerebral vein thrombosis is unknown. Aim: To compare efficacy and safety of a policy of short- (3–6 months) versus long-term (12 months) anticoagulation (any type venous thromboembolic events) after cerebral vein thrombosis for the prevention of venous th...


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