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Virulence gene repression promotes Listeria monocytogenes systemic infection

Pombinho, R; Vieira, A; Camejo, A; Archambaud, C; Cossart, P; Sousa, S; Cabanes, D

The capacity of bacterial pathogens to infect their hosts depends on the tight spatiotemporal regulation of virulence genes. The Listeria monocytogenes (Lm) metal efflux pump repressor CadC is highly expressed during late infection stages, modulating lipoprotein processing and host immune response. Here we investigate the potential of CadC as broad repressor of virulence genes. We show that CadC represses the e...

Date: 2020   |   Origin: Repositório Aberto da Universidade do Porto
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