7 documents found, page 1 of 1
Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f ...
Gonzalez-Diaz, Aida; Carrera-Salinas, Anna; Pinto, Miguel; Cubero, Meritxell; van der Ende, Arie; Langereis, Jeroen D.; Domínguez, M. ÁngelesHaemophilus influenzae is an opportunistic pathogen adapted to the human respiratory tract. Non-typeable H. influenzae are highly heterogeneous, but few studies have analysed the genomic variability of capsulated strains. This study aims to examine the genetic diversity of 37 serotype f isolates from the Netherlands, Portugal, and Spain, and to compare all capsulated genomes available on public databases. Serot...
Spatial and temporal genomic homogeneity among Haemophilus influenzae serotype f
Gonzalez-Diaz, Aida; Pinto, Miguel; Cubero, Meritxell; Langereis, Jeroen D.; van der Ende, Arie; Bajanca-Lavado, Maria Paula; Ardanuy, CarmenBackground: Haemophilus influenzae is an opportunistic pathogen highly adapted to the human respiratory tract which is often reported as the etiologic agent of infectious diseases. After the introduction of serotype b vaccine, non-typeable H. influenzae (NTHi) has become the most frequent cause of respiratory infection, followed in frequency by serotype f strains (Hif). The aim of this study was to analyze the ...
Antibody Binding and Complement-Mediated Killing of Invasive Haemophilus influe...
Dudukina, Elena; de Smit, Laura; Verhagen, Giel J.A.; van de Ende, Arie; Marimón, José María; Bajanca-Lavado, Paula; Ardanuy, Carmen; Marti, SaraHaemophilus influenzae is a Gram-negative bacterium that can be classified into typeable (types a through f) and nontypeable (NTHi) groups. This opportunistic pathogen asymptomatically colonizes the mucosal epithelium of the upper respiratory tract, from where it spreads to other neighboring regions, potentially leading to disease. Infection with NTHi can cause otitis media, sinusitis, conjunctivitis, exacerbat...
Ventilator-associated pneumonia diagnosis: a prioritization exercise based on m...
Ferreira-Coimbra, João; Ardanuy, Carmen; Diaz, Emili; Leone, Marc; De Pascale, Gennaro; Póvoa, Pedro; Prat-Aymerich, Cristina; Serrano-Garcia, RicardoThe aim was to provide global experts ranking on priorities in diagnostic tools for VAP in clinical practice. A multiple criteria decision analysis (MCDA) was performed to identify diagnosis tools for VAP diagnosis. Priority factors were identified after literature review. An international, multidisciplinary expert panel reviewed variables and ranked diagnostic tools. Experts from ten European hospitals partici...
Identification of polysaccharide capsules among extensively drug-resistant geni...
González-Díaz, Aida; Tubau, Fe; Pinto, Miguel; Sierra, Yanik; Cubero, Meritxell; Càmara, Jordi; Ayats, Josefina; Bajanca-Lavado, Paula; Ardanuy, CarmenThe human commensal Haemophilus parainfluenzae is emerging as an opportunistic multidrug-resistant pathogen. The objectives of this work were to characterise a new capsular operon of extensively drug-resistant (XDR) H. parainfluenzae clinical isolates and study their resistance mechanisms using whole-genome sequencing. All strains were resistant to: ß-lactams, via amino acid changes in PBP3 (S385T, I442F, V511A...
Detection of the Hmw adhesins in clinical Haemophilus influenzae isolates from ...
Bosh, Ana; González, Aida; Carrera-Salinas, Anna; Cubero, Meritxell; Marimón, José María; Bajanca-Lavado, Paula; Ardanuy, Carmen; Marti, SaraBackground: Non-typeable Haemophilus influenzae (NTHi) forms part of the normal nasopharyngeal microbiota in humans, but it is also an opportunistic pathogen causing respiratory infections and bacteraemia. Recently, high molecular weight (HMW1) proteins have been identified as a key factor for cell invasion, a feature implicated in persistence during chronic infection(a). Our aims were to identify the different...
Epidemiological analysis of invasive Haemophilus influenzae clinical isolates o...
Raeven, Elisabeth A.M.; González, Aida; van der Ende, Arie; Liñares, Josefina; Marimón, José María; Bajanca-Lavado, Paula; Langereis, Jeroen D.Background. Haemophilus influenzae is a human-restricted pathogen that forms part of the normal nasopharyngeal microbiota. The introduction of the H. influenzae serotype b vaccine has drastically decreased the number of bacteremia cases caused by H. influenzae serotype b (Hib). Conversely, the cases of non-typeable H. influenzae (NTHi) bacteremia have increased substantially. Therefore, we aimed to perform an e...