3 documents found, page 1 of 1
Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: w...
Arduíno, Daniela M.; Esteves, A. Raquel; Cardoso, Sandra M.Understanding the molecular basis of Parkinson's disease (PD) has proven to be a major challenge in the field of neurodegenerative diseases. Although several hypotheses have been proposed to explain the molecular mechanisms underlying the pathogenesis of PD, a growing body of evidence has highlighted the role of mitochondrial dysfunction and the disruption of the mechanisms of mitochondrial dynamics in PD and o...
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis
Branco, Diogo Martins; Arduíno, Daniela M.; Esteves, A. Raquel; Silva, Diana F. F.; Cardoso, Sandra M.; Oliveira, C. R.Parkinson's disease (PD) is the most common progressive neurodegenerative movement disorder, characterized by the selective loss of nigrostriatal dopaminergic neurons, and the presence of intracellular insoluble proteinaceous inclusions, known as Lewy Bodies. Although PD etiopathogenesis remains elusive, the leading hypothesis for the death of specific groups of neurons establishes that mitochondrial dysfunctio...
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 n...
Arduíno, Daniela M.; Esteves, A. Raquel; Domingues, A. Filipa; Pereira, Cláudia M. F.; Cardoso, Sandra M.; Oliveira, C. R.Recent studies have revealed that endoplasmic reticulum (ER) disturbance is involved in the pathophysiology of neurodegenerative disorders, contributing to the activation of the ER stress-mediated apoptotic pathway. Therefore, we investigated here the molecular mechanisms underlying the ER-mitochondria axis, focusing on calcium as a potential mediator of cell death signals. Using NT2 cells treated with brefeldi...