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Functional genetic variants in atg10 are associated with acute myeloid leukemia

Castro, I; Sampaio-Marques, B; Areias, AC; Sousa, H; Fernandes, Â; Sanchez-Maldonado, JM; Cunha, C; Carvalho, A; Sainz, J; Ludovico, P

Acute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic repro-gramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the ATG10 gene, central for the autophagosome formation. We sc...

Date: 2021   |   Origin: Repositório Aberto da Universidade do Porto
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