35 documents found, page 1 of 4
Association between sickle cell trait and Plasmodium falciparum infection
Silva, Ronise; Rodrigues, Amabélia; Arez, Ana Paula; Medeiros, Márcia M.Objectives Sickle cell trait (SCT) remains poorly documented in Guinea-Bissau. We aimed to investigate SCT frequency, its geographic-ethnic distribution, and association with Plasmodium falciparum infection. Methods DNA from 601 dried whole blood samples collected in the 2017 national malaria prevalence survey underwent β-globin genotyping. SCT ( HbAS ) and HbAA distributions were examined across health regions...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelBackground: Sickle Cell Anemia (SCA) is a monogenic disease, although its severity and response to treatment are very heterogeneous. Objectives: This study aims to characterize a cohort of Angolan children with SCA and evaluate their response to hydroxyurea (HU) treatment and the potential side effects and toxicity. Methods: The study enrolled 215 patients between 3 and 12 years old before and after the adminis...
Building a Lusophone Network of Biobanks and Biological Collections: opportunit...
Arez, Ana Paula; Couto, Isabel; Belo, SilvanaBiobanks and Biological Collections serve as central infrastructures for fundamental to scientific research and innovation, supporting various scientific fields, such as the preservation of biodiversity, food sciences or biotechnology, and particularly biomedical research. They provide essential resources for innovation and translation in global health, particularly for the development of new biomarkers, therap...
Empowering portuguese-speaking women inTropical Health sciences:the journey of ...
Maurício, Isabel L.; Domingos, Ana; Arez, Ana Paula; Conceição, Cláudia; Couto, Isabel; Oliveira Martins, Maria do Rosário; Campino, LeneaFemale participation in science, including biomedical sciences, has increased, but still presents various challenges. The MulhereSTrop network was launched in 2015 to support women scientists in African Portuguese speaking countries (PALOP) inTropical Health.The network has offered workshops on scientific writing and has encouraged scientific article submission, with awards for the best. Through the website, th...
Sickle cell disease and gut health: the influence of intestinal parasites and t...
Delgadinho, Mariana; Ginete, Catarina; Santos, Brígida; Vasconcelos, Jocelyne Neto; Arez, Ana Paula; Brito, MiguelParasitic infections are a common problem in developing countries and can intensify morbidity in patients with sickle cell disease (SCD), increasing the severity of anemia and the need for transfusions. It has been demonstrated that both helminths and protozoa can affect gut microbiome composition. On the other hand, the presence of specific bacterial communities can also influence parasite establishment. Consi...
Sickle cell disease: current drug treatments and functional foods with therapeu...
Gonçalves, Elisângela; Smaoui, Slim; Brito, Miguel; Oliveira, J. M.; Arez, Ana Paula; Tavares, LolenySickle cell anemia (SCA), the most common form of sickle cell disease (SCD), is a genetic blood disorder. Red blood cells break down prematurely, causing anemia and often blocking blood vessels, leading to chronic pain, organ damage, and increased infection risk. SCD arises from a single-nucleotide mutation in the β-globin gene, substituting glutamic acid with valine in the β-globin chain. This review examines ...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelBackground: Sickle Cell Anemia (SCA) is a monogenic disease, although its severity and response to treatment are very heterogeneous. Objectives: This study aims to characterize a cohort of Angolan children with SCA and evaluate their response to hydroxyurea (HU) treatment and the potential side effects and toxicity. Methods: The study enrolled 215 patients between 3 and 12 years old before and after the adminis...
Characterization of a cohort of Angolan children with sickle cell anemia treate...
Santos, Brígida; Ginete, Catarina; Gonçalves, Elisângela; Delgadinho, Mariana; Miranda, Armandina; Faustino, Paula; Arez, Ana Paula; Brito, MiguelBackground: Sickle Cell Anemia (SCA) is a monogenic disease, although its severity and response to treatment are very heterogeneous. Objectives: This study aims to characterize a cohort of Angolan children with SCA and evaluate their response to hydroxyurea (HU) treatment and the potential side effects and toxicity. Methods: The study enrolled 215 patients between 3 and 12 years old before and after the adminis...
Assessing the burden of submicroscopic Plasmodium infections in a pre-eliminati...
Silva, Ronise; Lopes, Luis Filipe; Rodrigues, Amabelia; Arez, Ana Paula; Medeiros, Márcia M.Background Submicroscopic Plasmodium infections can be a source of persistent malaria transmission. The aim of this study was to assess their frequency, distribution, morbidity and associated factors in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau, where the Plasmodium falciparum is the predominant Plasmodium species. Methods Dried fingerprick whole blood samples from 601 participants ...
Modulação genética da gravidade da anemia hemolítica e de eventos clínicos adve...
Germano, Isabel; Santos, Brígida; Delgadinho, Mariana; Ginete, Catarina; Miranda, Armandina; Lopes, Pedro; Arez, Ana Paula; Brito, MiguelA anemia das células falciformes (SCA), ou drepanocitose, é uma doença genética recessiva causada pela mutação c.20A>T no gene da beta-globina (HBB), caracterizada pela presença de eritrócitos falciformes, anemia hemolítica crónica e eventos vaso-oclusivos, entre outros. As manifestações clínicas da doença são muito heterogéneas devido a agentes modificadores ambientais e genéticos. Neste estudo pretendeu-se in...