10 documents found, page 1 of 1
ZIKV Strains Elicit Different Inflammatory and Anti-Viral Responses in Microgli...
Oliveira, Fernanda Bellaniza Caminha de; Freire, Vanessa Paola Alves Sampaio de Sá; Coelho, Sharton Vinicius Antunes; Meuren, Lana MonteiroIn recent years, the Zika Virus (ZIKV) has caused pandemic outbreaks associated with a high rate of congenital ZIKV syndrome (CZS). Although all strains associated with worldwide outbreaks derive from the Asian lineage, the reasons for their enhanced spread and severity are not fully understood. In this study, we conducted a comparative analysis of miRNAs (miRNA-155/146a/124) and their cellular targets (SOCS1/3...
Alpha‐1‐antitrypsin : a possible host protective factor against Covid‐19
Loyola, Mariana Braccialli de; Reis, Thaís Tereza Aguiar dos; Oliveira, Guilherme Xavier Lyra Malcher de; Palmeira, Julys da FonsecaUnderstanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the ...
Phosphatidylserine inside out : a possible underlying mechanism in the infammat...
Argañaraz, Gustavo Adolfo; Palmeira, Julys da Fonseca; Argañaraz, Enrique RobertoThe rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems worldwide. The acute inflammation and coagulation abnormalities appear as the main causes for thousands of deaths worldwide. The intense inflammatory response could be involved with the formation of thrombi. ...
ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19
Zipeto, Donato; Palmeira, Julys da Fonseca; Argañaraz, Gustavo Adolfo; Argañaraz, Enrique RobertoThe Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the...
Emerging Chagas Disease : trophic network and cycle of transmission of Trypanos...
Teixeira, Antonio Raimundo Lima Cruz; Monteiro, Pedro Sadi; Rebêlo, José Manuel Macário; Argañaraz, Enrique Roberto; Vieira, DanielaABSTRACT; A trophic network involving molds, invertebrates, and vertebrates, ancestrally adapted to the palm tree (Attalaea phalerata) microhabitat, maintains enzootic Trypanosoma cruzi infections in the Amazonian county Paço do Lumiar, state of Maranhão, Brazil. We assessed seropositivity for T. cruzi infections in the human population of the county, searched in palm trees for the triatomines that harbor these...
Hitchhiking Trypanosoma cruzi minicircle DNA affects gene expression in human h...
Barbosa, Augusto Mello Simões; Argañaraz, Enrique Roberto; Costa, Ana Maria; Rosa, Ana de Cassia Oliveira Cardoso; Alves, Nivaldo PereiraThe horizontal transfer of Trypanosoma cruzi mitochondrial minicircle DNA to the genomes of naturally infected humans may play an important role in the pathogenesis of Chagas disease. Minicircle integrations within LINE-1 elements create the potential for foreign DNA mobility within the host genome via the machinery associated with this retrotransposon. Here we document integration of minicircle DNA fragments i...
Integration of Trypanosoma cruzi kDNA minicircle sequence in the host genome ma...
Barbosa, Augusto Mello Simões; Barros, Ana Maria; Nitz, Nadjar; Argañaraz, Enrique Roberto; Teixeira, Antonio Raimundo Lima CruzABSTRACT: Integration of kDNA sequences within the genome of the host cell shown by PCR amplification with primers to the conserved Trypanosoma cruzi kDNA minicircle sequence was confirmed by Southern hybridization with specific probes. The cells containing the integrated kDNA sequences were then perpetuated as transfected macrophage subclonal lines. The kDNA transfected macrophages expressed membrane antigens ...
Blood-sucking lice may disseminate Trypanosoma cruzi infection in baboons
Argañaraz, Enrique Roberto; Hubbard, Gene B.; Ramos, Larissa Acosta; Ford, Allen L.; Nitz, Nadjar; Leland, Michelle M.; Vandeberg, John L.As infecções pelo Trypanosoma cruzi e a doença de Chagas são endêmicas em babuínos (Papio hamadryas) reproduzidos em cativeiro na Southwest Foundation for Biomedical Research, em Santo Antonio, Texas. Nós obtivemos produtos de amplificação por PCR do DNA extraído de piolhos colhidos do cabelo e da pele de babuínos chagásicos, com primers aneladores específicos para DNAs nuclear e de cinetoplasto do protozoário....
Persistent infections in chronic Chagas’ disease patients treated with anti-Try...
Braga, Maria do Socorro Costa Oliveira; Pires, Liana Lauria; Argañaraz, Enrique Roberto; Nascimento, Rubens José doUsamos um método molecular e demonstramos que o tratamento de infecções crônicas pelo Trypanosoma cruzi com nitroderivados, que se mostraram eficientes em diminuir parasitemias nas infecções agudas, não produziu cura parasitológica. Trinta e quatro chagásicos crônicos, com pelo menos dois entre três testes sorológicos positivos para a infecção, e 17 controles com testes sorológicos negativos formaram os grupos ...
Current millennium biotechniques for biomedical research on parasites and host-...
Teixeira, Antonio Raimundo Lima Cruz; Barbosa, Augusto Mello Simões; Faudry, Eric; Lozzi, Silene de Paulino; Argañaraz, Enrique RobertoThe development of biotechnology in the last three decades has generated the feeling that the newest scientific achievements will deliver high standard quality of life through abundance of food and means for successfully combating diseases. Where the new biotechnologies give access to genetic information, there is a common belief that physiological and pathological processes result from subtle modifications of ...