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Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondria...

Walter, Jonas; Bolognin, Silvia; Antony, Paul M. A.; Nickels, Sarah L.; Poovathingal, Suresh K.; Salamanca, Luis; Magni, Stefano; Perfeito, Rita

Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a crucial cofactor in its etiology. Here, we show that PD patient-specific human neuroepithelial stem cells (NESCs), carrying the LRRK2-G2019S mutation, recapitulate key mitochondrial defects previously d...

Date: 2019   |   Origin: Estudo Geral - Universidade de Coimbra
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