5 documents found, page 1 of 1
Neuroprotective effects of platinum nanoparticle-based microreactors in bicucul...
Oliveira, Roberto N.; Carvalhinho-Lopes, Patrícia S.; Carvalho, Carolina P. F.; Hirata, Rafael Y. S.; Vaz, Sandra H.; Sebastião, Ana MEpilepsy designates a group of chronic brain disorders, characterized by the recurrence of hypersynchronous, repetitive activity, of neuronal clusters. Epileptic seizures are the hallmark of epilepsy. The primary goal of epilepsy treatment is to eliminate seizures with minimal side effects. Nevertheless, approximately 30% of patients do not respond to the available drugs. An imbalance between excitatory/inhibit...
Platinum nanoparticle-based microreactors protect against the behavioral and ne...
Hirata, Rafael Y. S.; Oliveira, Roberto N.; Silva, Mariana S. C. F.; Armada-Moreira, Adam; Vaz, Sandra H.; Ribeiro, Filipa; Sebastião, Ana MExcitotoxicity is described as the exacerbated activation of glutamate AMPA and NMDA receptors that leads to neuronal damage, and ultimately to cell death. Astrocytes are responsible for the clearance of 80-90% of synaptically released glutamate, preventing excitotoxicity. Chronic stress renders neurons vulnerable to excitotoxicity and has been associated to neuropsychiatric disorders, i.e., anxiety. Microreact...
Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegener...
Armada-Moreira, Adam; Gomes, Joana I.; Pina, Carolina Campos; Savchak, Oksana K.; Gonçalves-Ribeiro, Joana; Rei, Nádia; Pinto, Sara; Morais, Tatiana P.Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss of neuronal function and cell death. In this process, the shift between normal physiological function and excitotoxicity is largely controlled by astrocytes si...
Astrosomes : a novel approach for the regulation of neuronal communication
Armada-Moreira, Adam
Multicompartment microreactors prevent excitotoxic dysfunctions in rat primary ...
Armada-Moreira, Adam; Coelho, Joana E; Lopes, Luisa V.; Sebastião, Ana M; Städler, Brigitte; Vaz, Sandra H.Excitotoxicity is a cellular phenomenon that comprises the consequences of toxic actions of excitatory neurotransmitters, such as glutamate. This process is usually related to overproduction of reactive oxygen species (ROS) and ammonia (NH4+ ) toxicity. Platinum nanoparticle (Pt-NP)-based microreactors able to degrade hydrogen peroxide (H2 O2 ) and NH4+ , are previously described as a novel therapeutical approa...