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RIBEIRA | Entre duas escarpas, uma linha de água
David, Paulo; Arnaut, Daniela; Monteiro, Ângela; Oliveira, Clara; Arez, Leandro; Baptista, Manuel; Mendonça, Maria; Sousa, Maria Salazar de
Date: 2023
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Origin: DigitUMa - Repositório da Universidade da Madeira
Livro de atas do V Seminário Internacional de História de Arquitetura Hospitala...
Brasileiro, Carolina; Arnaut, Daniela; Nunes, José Carlos Avelãs; Ferreira, Patrícia; Providência, Paulo
Date: 2023
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Origin: Estudo Geral - Universidade de Coimbra
Genetic testing for germline variants in homologous recombination repair genes,...
Arnaut, Daniela; Rodrigues, Pedro; Theisen, Patrícia; Carpinteiro, Dina; Vieira, Luís; Gonçalves, JoãoHomologous recombination repair (HRR) is the cellular mechanism for error-free repair of DNA double-strand breaks. Pathogenic germline variants in BRCA1 and BRCA2 lead to HRR deficiency associated with breast, ovarian, prostate, pancreatic cancers and are sensitive to PARP inhibitors (PARPi). Defects in HRR genes beyond BRCA1/2 could also result in HRR deficiency and sensitize the tumor to PARPi, thus expanding...
Date: 2023
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Origin: Repositório Científico do Instituto Nacional de Saúde