6 documents found, page 1 of 1
Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 mo...
Sousa, Paula; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena Tavares; Ministro, Paula; Mocanu, Irina; Vieira, AnaThe emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. Aims: To clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab. Methods: In this analysis of the 2 -year prospective multicentric DIRECT study, patients were assessed in terms of clinical ac...
How many biomarker measurements are needed to predict prognosis in Crohn's dise...
Magro, Fernando; Estevinho, Maria Manuela; Catalano, Gaia; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena TavaresBackgroundTimely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. ObjectiveWe aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression. MethodsData from 289 CD patients receiving infl...
Clinical performance of new software to automatically detect angioectasias in s...
Costa, Dalila Amélia Amorim; Vieira, Pedro Miguel; Pinto, Catarina; Arroja, Bruno; Leal, Tiago; Mendes, Sofia Silva; Gonçalves, Raquel; Lima, C. S.Background: Video capsule endoscopy (VCE) revolutionized the diagnosis and management of obscure gastrointestinal bleeding, though the rate of detection of small bowel lesions by the physician is still disappointing. Our group developed a novel algorithm (CMEMS-Uminho) to automatically detect angioectasias which display greater accuracy in VCE static frames than other methods previously published. We aimed to e...
Role of a micronized purified flavonoid fraction as an adjuvant treatment to ru...
Caetano, Ana Célia; Cunha, Catarina; Arroja, Bruno; Costa, Dalila Amélia Amorim; Rolanda, CarlaNonsurgical treatment of hemorrhoidal disease (HD) includes medical and instrumental techniques. We aimed to compare the efficacy of the most frequently used nonsurgical strategies, either alone or in combination, applied in an ambulatory setting. Purpose: Nonsurgical treatment of hemorrhoidal disease (HD) includes medical and instrumental techniques. We aimed to compare the efficacy of the most frequently used...
Isolated gastric Kaposi's sarcoma
Costa, Dalila Amélia Amorim; Carvalho, Sofia; Rolanda, Carla; Arroja, Bruno[Excerpt] A 47-year-old male patient presented with a 6-month A B history of epigastric pain, anorexia, weight loss of 10 kg, and night sweats. He confirmed engaging in high-risk sexual behavior. Physical examination was unremarkable, except for mild epigastric tenderness on abdominal palpation.[...]
Accuracy of the new rapid test for monitoring adalimumab levels
Rocha, Cátia; Afonso, Joana; Lago, Paula; Arroja, Bruno; Vieira, Ana I.; Dias, Cláudia C.; Magro, FernandoBackground: The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly...